PMID: 9655913Jul 10, 1998Paper

Identification and sequencing of a cytochrome P450 gene cluster from Bradyrhizobium japonicum

Biochimica Et Biophysica Acta
Raymond E. TullyDonald L. Keister

Abstract

Sequencing of a region from Bradyrhizobium japonicum previously shown to encode for cytochromes P450 revealed a cluster of three complete P450 genes (CYP112, CYP114, and CYP117) plus a partial P450 gene fragment (CYP115P). Present also are five additional open reading frames. The close positioning of the genes suggests that they comprise an operon. Although the biochemical function of the gene products is uncertain, the similarities to other genes suggests an operon involved in terpenoid synthesis. ORF3 has similarity to a [3Fe-4S] ferredoxin from Streptomyces griseolus. ORF4 has strong similarity to members of the short chain alcohol dehydrogenase family, including sterol dehydrogenases from enteric bacteria and to some plant 3-oxoacyl-(acyl carrier protein) reductases. ORF6 has strong similarity to prenyl transferases, including dimethylallyltranstransferase from Escherichia coli. ORF7 bears some similarity to plant genes for ent-kaurene synthase (a precursor of gibberellins), and to bacterial squalene-hopene cyclases. ORF8 has some similarity to a Streptomyces gene for synthesis of the cyclic sesquiterpene pentalenene. The 5' end of the mRNA transcript is 38-39 nucleotides downstream from the center of a motif that bears seq...Continue Reading

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Citations

Dec 12, 2001·The Journal of Steroid Biochemistry and Molecular Biology·S Al-AwadiS Oommen
Nov 1, 2005·Plant Physiology·Sam LievensMarcelle Holsters
May 11, 2002·Journal of Bacteriology·John T SullivanClive W Ronson
Nov 10, 2001·Annual Review of Phytopathology·K GoethalsM Holsters
Jan 1, 2014·Phytochemistry·Constanza MéndezMaría Cecilia Rojas
Mar 29, 2014·Journal of Integrative Plant Biology·Satomi HayashiBrett J Ferguson
Nov 15, 2016·Nature Chemical Biology·Ryan S NettReuben J Peters
Jan 14, 2010·Journal of Biochemistry·Tsuneo Omura
Dec 27, 2002·The Journal of General and Applied Microbiology·Donald L. KeisterPeter Van Berkum
Jul 5, 2001·Molecular Plant-microbe Interactions : MPMI·E LuytenJ Vanderleyden
Dec 14, 2018·Frontiers in Microbiology·Raimund NagelReuben J Peters
Nov 2, 2021·Journal of Applied Microbiology·Chetan KeswaniEstibaliz Sansinenea

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