Identification and structural characterization of the synthetic cannabinoid 3-(1-adamantoyl)-1-pentylindole as an additive in 'herbal incense'

Journal of Mass Spectrometry : JMS
Stefan KneiselVolker Auwärter

Abstract

Since the end of 2010, more than 20 synthetic cannabimimetics have been identified in 'Spice' products, demonstrating the enormous dynamic in this field. In an effort to cope with the problem, many countries have already undertaken legal measures by putting some of these compounds under control. Nevertheless, once a number of compounds were scheduled, they were soon replaced by other synthetic cannabinoids. In this article, we report the identification of a new--and due to its substitution pattern rather uncommon--cannabimimetic found in several 'herbal incense' products. The GC-EI mass spectrum first led to misidentification as the alpha-methyl-derivative of JWH-250. However, since both substances show different retention indices, thin-layer chromatography was used to isolate the unknown compound. After application of nuclear magnetic resonance spectroscopy, high-resolution MS and GC-MS/MS techniques, the compound was identified as 3-(1-adamantoyl)-1-pentylindole, a derivative of JWH-018 carrying an adamantoyl moiety instead of a naphthoyl group. This finding supports that the listing of synthetic cannabinoids as prohibited substances triggers the appearance of compounds with uncommon substituents. Moreover, it emphasizes the ...Continue Reading

References

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Citations

Jul 10, 2013·Psychopharmacology·Max SpadernaDeepak Cyril D'Souza
May 3, 2013·International Journal of Legal Medicine·Frank MusshoffVolker Auwärter
Apr 5, 2013·ACS Chemical Neuroscience·Samuel D BanisterMichael Kassiou
Oct 12, 2013·Life Sciences·Anita H LewinP Anantha Reddy
Jul 28, 2012·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Melanie HutterMerja A Neukamm
Oct 9, 2012·Drug Testing and Analysis·Tim SobolevskyGrigory Rodchenkov
Jan 30, 2014·Biomedical Chromatography : BMC·Nadine SchaeferAndreas H Ewald
Nov 28, 2014·Drug Testing and Analysis·Tim SobolevskyGrigory Rodchenkov
Aug 11, 2015·Forensic Toxicology·Akira NameraMasataka Nagao
Jan 1, 2014·Forensic Science International : Synergy·Folker WestphalSiegfried Knecht
Nov 14, 2014·Journal of Dual Diagnosis·Andreja CelofigaJanez Klavz

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