Nov 1, 1975

Identification and urinary excretion of p-chlorophenoxyacetamide, a metabolite of iproclozide, in humans

Drug Metabolism and Disposition : the Biological Fate of Chemicals
R M de SagherA E Claeys

Abstract

The presence of p-chlorophenoxyacetamide was detected in the urine of man receiving iproclozide [1-(p-chlorophenoxyacetyl)-2-isopropylhydrazine]. This new metabolite was identified by combined gas-liquid chromatography-mass spectrometry and by comparison with the synthetic compound. An appropriate procedure for the extraction and quantitation of p-chlorophenoxyacetamide by gas-liquid chromatography on a 5% OV-225-packed column with the 2-butyl analog of iproclozide as an internal standard, has been developed. After 20- and 50-mg single dose oral administrations of iproclozide, 5.2 and 8.3% were slowly excreted in urine as p-chlorophenoxyacetamide within 30.5 and 36 hr. respectively. After 20-mg oral intakes by psychiatric patients, the 24-hr urinary excretion of p-chlorophenoxyacetamide amounted to about 2-4% of the iproclozide dose administered.

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Mentioned in this Paper

Urine
Psychiatric Inpatient
Acetamides
Hydrazines
Mass Spectrometry
Body Excretions
RIMA (Reversible Inhibitor of Monoamine Oxidase A)
Glycolate Ethers
Excretory Function
Chromatography, Gas-Liquid

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