Identification and Validation of Immune-Related lncRNA Signature as a Prognostic Model for Skin Cutaneous Melanoma.

Pharmacogenomics and Personalized Medicine
Shuai PingJianghai Chen

Abstract

Skin cutaneous melanoma (SKCM) is the most aggressive skin cancer that results in high morbidity and mortality rate worldwide. Immune-related long non-coding RNAs (IRlncRs) play an important role in regulating gene expression in tumors. Therefore, in this study, we aimed to identify IRlncRs signature that could predict prognosis and therapeutic targets for melanoma irrespective of the gene expression levels. RNA-sequencing data were obtained from The Cancer Genome Atlas (TCGA). IRlncRs were identified using co-expression analysis and recognized using univariate analysis. The impact of IRlncRs on survival was analyzed using a modified least absolute shrinkage and selection operator (Lasso) regression model. A 1-year survival receiver operating characteristic curve was constructed, and the area under the curve was calculated to identify the optimal cut-off point to distinguish between high and low-risk groups in patients with SKCM. Furthermore, integrative analysis was performed to identify the impact of clinicopathological features, chemotherapeutic treatment, tumor-infiltrating immune cells, and mutant genes on survival. A total of 28 IRlncRs significantly associated with survival were identified. Seventeen IRlncRs pairs were u...Continue Reading

References

Apr 30, 2004·The New England Journal of Medicine·Izidore S LossosRonald Levy
Aug 23, 2016·Nature Reviews. Immunology·Sabra L Klein, Katie L Flanagan
Jan 24, 2017·The Cancer Journal·Praveen K BommareddyHoward L Kaufman
Jan 27, 2017·Annual Review of Immunology·Maninjay K AtianandKatherine A Fitzgerald
Aug 23, 2017·Nature Immunology·Y Grace ChenHoward Y Chang
Nov 17, 2017·Genome Biology·Dvir AranAtul J Butte
Dec 13, 2017·Cancer Metastasis Reviews·Qihong HuangReuven Agami
Jan 19, 2018·Methods in Molecular Biology·Binbin ChenAsh A Alizadeh
Feb 14, 2018·International Journal of Oncology·Shuocheng YangXuan Zeng
Jun 21, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yufeng LvZihai Xu
Aug 11, 2018·Journal of Cancer Research and Clinical Oncology·Harshita MishraSushama Talegaonkar
Feb 8, 2019·Journal of the American Academy of Dermatology·Claudia C DarmawanJe-Ho Mun
May 31, 2019·Journal of the National Cancer Institute·Elizabeth M WardKathleen A Cronin
Mar 18, 2020·Methods in Enzymology·Christina PlattnerDietmar Rieder
Mar 20, 2020·American Journal of Public Health·Juliana Berk-KraussAlan C Geller
Apr 9, 2020·The Journal of Investigative Dermatology·Russell W Jenkins, David E Fisher
Jun 18, 2020·Clinical & Translational Immunology·Menno TammingaHarry Jm Groen
Jul 29, 2020·Genome Research·Jordan A RamilowskiPiero Carninci
Nov 7, 2020·European Review for Medical and Pharmacological Sciences·Z-H GuoA-Y Guo
Jan 13, 2021·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

ggupbr
Perl
MCPcounter
EPIC
survivalROC
R packages “ survival ”
survminer
TIMER
limma
R language

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.