Identification and Validation of Lymphovascular Invasion as a Prognostic and Staging Factor in Node-Negative Esophageal Squamous Cell Carcinoma

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Qingyuan HuangJian-Hua Fu

Abstract

Lymphovascular invasion (LVI) is a histopathological feature that is associated with an increased risk for micrometastasis. The aim of this study was to determine the prognostic and staging value of LVI among patients with esophageal squamous cell carcinoma (ESCC) undergoing esophagectomy. A prospective database of patients with ESCC was used to retrospectively analyze 666 cases to identify the relationship between LVI and survival, and to evaluate predictive accuracy of prognosis after combining LVI and the tumor, node, and metastasis (TNM) system. Pathological slides were reassessed by gastrointestinal pathologists according to the strict criteria; 1000-bootstrap resampling was used for internal validation, and 222 cases from an independent multicenter database were used for external validation. LVI was present in 33.8% of patients, and the proportion increased with advancing T and N classification. LVI was an independent predictor of unfavorable disease-specific survival (DSS) (hazard ratio = 1.59, 95% confidence interval: 1.30-1.94) and disease-free survival (DFS) (hazard ratio = 1.62, 95% confidence interval: 1.32-1.98) after T classification. Among node-negative patients, LVI and T classification were two independent pred...Continue Reading

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Citations

Jul 6, 2016·Journal of Cancer Research and Clinical Oncology·Jizhuang LuoHaiquan Chen
Sep 1, 2018·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·A WangS Wang
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Dec 23, 2021·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Tetsuro ToriumiYasuyuki Seto

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