Jun 29, 2017

Identification and visualization of differential isoform expression in RNA-seq time series

BioRxiv : the Preprint Server for Biology
María José NuedaAna Conesa

Abstract

Motivation: As sequencing technologies improve their capacity to detect distinct transcripts of the same gene and to address complex experimental designs such as longitudinal studies, there is a need to develop statistical methods for the analysis of isoform expression changes in time series data. Results: Iso-maSigPro is a new functionality of the R package maSigPro for transcriptomics time series data analysis. Iso-maSigPro identifies genes with a differential isoform usage across time. The package also includes new clustering and visualization functions that allow grouping of genes with similar expression patterns at the isoform level, as well as those genes with a shift in major expressed isoform. Availability: The package is freely available under the LGPL license from the Bioconductor web site.

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Mentioned in this Paper

Patterns
Genes
Longitudinal Studies
Nucleic Acid Sequencing
Site
Sequencing
License
Protein Isoforms
Analysis
1-(5-isoquinolinylsulfonyl)-3-methylpiperazine

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