PMID: 9540832Apr 16, 1998Paper

Identification, cloning and sequence of the Aspergillus niger areA wide domain regulatory gene controlling nitrogen utilisation

Biochimica Et Biophysica Acta
A P MacCabeJ Visser

Abstract

The gene encoding the positive-acting regulator of nitrogen metabolite repression (AREA) has been cloned and characterised from the industrially important filamentous fungus Aspergillus niger. The deduced amino acid sequence has an overall level of identity with its homologues from other fungal species which varies between 32 and 72%. This gene (areAnig) complements the A. nidulans areAr-18 loss-of-function mutation. Sequences upstream of the structural gene contain several putative GATA-type zinc finger protein-binding motifs. Northern analysis indicates the synthesis of multiple transcripts, the major species being approximately 2.95 kb and 3.1 kb. Maximal expression of areAnig is observed under conditions of nitrogen starvation and is mainly due to an increase in the level of the shorter transcript.

References

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Citations

Jul 27, 2002·Journal of Biotechnology·A P MacCabeD Ramón
Mar 18, 2006·Advances in Applied Microbiology·O P WardA Singh
Dec 3, 1999·Applied and Environmental Microbiology·R P de Vries, J Visser

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