PMID: 9440523Jan 24, 1998Paper

Identification, genomic organization, and analysis of the group III capsular polysaccharide genes kpsD, kpsM, kpsT, and kpsE from an extraintestinal isolate of Escherichia coli (CP9, O4/K54/H5)

Journal of Bacteriology
T A RussoA J Lesse

Abstract

Group III capsular polysaccharides (e.g., K54) of extraintestinal isolates of Escherichia coli, similar to group II capsules (e.g., K1), are important virulence traits that confer resistance to selected host defense components in vitro and potentiate systemic infection in vivo. The genomic organization of group II capsule gene clusters has been established as a serotype-specific region 2 flanked by regions 1 and 3, which contain transport genes that are highly homologous between serotypes. In contrast, the organization of group III capsule gene clusters is not well understood. However, they are defined in part by an absence of genes with significant nucleotide homology to group II capsule transport genes in regions 1 and 3. Evaluation of isogenic, TnphoA-generated, group III capsule-minus derivatives of a clinical blood isolate (CP9, O4/K54/H5) has led to the identification of homologs of the group II capsule transport genes kpsDMTE. These genes and their surrounding regions were sequenced and analyzed. The genomic organization of these genes is distinctly different from that of their group II counterparts. Although kps(K54)DMTE are significantly divergent from their group II homologs at both the DNA and protein levels phoA fus...Continue Reading

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Citations

Mar 29, 2013·Future Microbiology·Biao YuanMingshu Wang
Feb 17, 2001·Infection and Immunity·J R JohnsonP Delavari
Apr 14, 1999·Molecular Microbiology·C Whitfield, I S Roberts
Jun 28, 2019·Frontiers in Cellular and Infection Microbiology·Ana Paula DagaEliana Carolina Vespero
Dec 1, 2004·EcoSal Plus·James R Johnson, Thomas A Russo
Sep 15, 2004·Journal of Clinical Microbiology·Jennifer A SchuchertS Jessing
Apr 19, 2018·EcoSal Plus·James R Johnson, Thomas A Russo
Oct 22, 2005·International Journal of Medical Microbiology : IJMM·James R Johnson, Thomas A Russo

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