PMID: 2107103Feb 26, 1990Paper

Identification in human erythrocytes of mono(ADP-ribosyl) protein hydrolase that cleaves a mono(ADP-ribosyl) Gi linkage

FEBS Letters
S Tanuma, H Endo

Abstract

A novel enzymatic activity, the hydrolysis of linkages between mono(ADP-ribose) and cysteine residues in Gi prepared by eukaryotic ADP-ribosyltransferase C [(1988) J. Biol. Chem. 263, 5485-5489] was found in the cytosol of human erythrocytes. The mono(ADP-ribosyl) Gi hydrolase, tentatively named ADP-ribosyl protein hydrolase C was partially purified by sequential chromatographies on DEAE-cellulose and Blue Sepharose. This enzyme catalyzes the release of ADP-ribose from mono(ADP-ribosyl) Gi. Its activity was enhanced by Ca2+ and inhibited by ADP-ribose. The presence of this enzyme in eukaryotic cells suggests that endogenous mono(ADP-ribosyl)ation of Gi is a reversible post-translational modification.

References

Sep 15, 1989·Biochemical and Biophysical Research Communications·S Tanuma
Jan 1, 1987·Annual Review of Biochemistry·M J Berridge
Mar 1, 1987·Journal of Biochemistry·S TanumaH Endo
Jan 1, 1981·Current Topics in Cellular Regulation·M Vaughan, J Moss
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·H Lee, W J Iglewski
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·T Katada, M Ui

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Citations

Sep 1, 1994·Molecular and Cellular Biochemistry·L J McDonald, J Moss
Nov 1, 1994·Biochemical Pharmacology·L E DonnellyJ MacDermot
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A ZolkiewskaJ Moss
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·V Pancholi, V A Fischetti
Sep 9, 2006·Microbiology and Molecular Biology Reviews : MMBR·Paul O HassaMichael O Hottiger
Sep 9, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Maria Cristina AlbertiniMarina Dachà
May 15, 1991·Biochemical and Biophysical Research Communications·K InagedaS Tanuma
Oct 15, 1992·Biochemical and Biophysical Research Communications·L GuidaA De Flora

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