Identification of 2 Potential Core Genes for Influence of Gut Probiotics on Formation of Intracranial Aneurysms by Bioinformatics Analysis

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Heng-Jian LiuYu-Gong Feng

Abstract

BACKGROUND Rupture of intracranial aneurysms (IA) is associated with high rates of mortality around the world. Use of intestinal probiotics can regulate the pathophysiology of aneurysms, but the details of the mechanism involved have been unclear. MATERIAL AND METHODS The GEO2R analysis website was used to detect the DEGs between IAs, AAAs, samples after supplementation with probiotics, and normal samples. The online tool DAVID provides functional classification and annotation analyses of associated genes, including GO and KEGG pathway. PPI of these DEGs was analyzed based on the STRING database, followed by analysis using Cytoscape software. RESULTS We found 170 intersecting DEGs (contained in GSE75240 and more than 2 of the 4 aneurysms datasets), 5 intersecting DEGs (contained in all datasets) and 1 intersecting DEG (contained in GSE75240 and all IAs datasets). GO analysis results suggested that the DEGs primarily participate in signal transduction, cell adhesion, immune response, response to drug, extracellular matrix organization, cell-cell signaling, and inflammatory response in the BP terms, and the KEGG pathways are mainly enriched in focal adhesion, cytokine-cytokine receptor interaction, ECM-receptor interaction, amoeb...Continue Reading

Citations

Aug 24, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Liwei YuTong Xu

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Datasets Mentioned

BETA
GSE54083
GSE75436
GSE7084
GSE75240
GPL11649
GSE26969

Methods Mentioned

BETA
chip

Software Mentioned

TBtoolsv0
Venn
Search Tool for the
Cytoscape3
TBtools
Cytoscape
CytoHubba

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