Identification of a BglI polymorphism of catechol-O-methyltransferase (COMT) gene, and association study with schizophrenia

American Journal of Medical Genetics
C H ChenK J Hsiao

Abstract

Several linkage studies suggested chromosome 22q11-13 may harbor susceptible genes for schizophrenia. Catechol-O-methyl-transferase (COMT), which is involved in the metabolism of catecholamines, was mapped to 22q11 and is considered a possible candidate gene for schizophrenia. Recently, we identified a polymorphic marker, a single nucleotide C insertion at the 3' untranslated region of the COMT gene, which obliterates a BglI site. Using this BglI polymorphism, we conducted a case-control association study in Chinese patients with schizophrenia. No significant differences of allele and genotype frequencies were noted between patients (N = 177) and controls (N = 99). When patients were subgrouped according to sex, no significant differences of genotype and allele frequencies were noted in either male or female patients compared to normal controls. Our results do not support an association between the BglI polymorphism of COMT gene and schizophrenia.

References

Jan 1, 1992·American Journal of Medical Genetics·R J ShprintzenR W Marion
Mar 1, 1991·Schizophrenia Research·M T TsuangS V Faraone
Mar 1, 1989·Archives of General Psychiatry·M H RapaportS M Paul
Mar 1, 1989·Archives of General Psychiatry·R Ganguli, B S Rabin
Sep 1, 1988·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A Carlsson
Apr 24, 1995·American Journal of Medical Genetics·H P ValladaD Collier
Apr 24, 1995·American Journal of Medical Genetics·V K LasseterL Kasch
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·M KarayiorgouV K Lasseter
Mar 15, 1994·American Journal of Medical Genetics·A E PulverG Nestadt
Mar 15, 1994·American Journal of Medical Genetics·H CoonW Byerley
Aug 1, 1994·The Journal of Nervous and Mental Disease·A E PulverD Housman
Jun 15, 1994·American Journal of Medical Genetics·M H PolymeropoulosA M Smith
Jan 1, 1993·European Archives of Psychiatry and Clinical Neuroscience·M H RapaportS M Paul
Oct 9, 1995·American Journal of Medical Genetics·S G SchwabM Ackenheil
Oct 9, 1995·American Journal of Medical Genetics·V L NimgaonkarR Ganguli
Oct 9, 1995·American Journal of Medical Genetics·H W MoisesI I Gottesman

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Citations

Dec 7, 2007·The International Journal of Clinical and Experimental Hypnosis·Amir Raz
Sep 27, 2007·CNS Drug Reviews·Maria João BonifácioPatrício Soares-da-Silva
Mar 10, 2004·Molecular Psychiatry·B J MowryD F Levinson
Apr 23, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·I KremerR P Ebstein
Mar 19, 2014·Frontiers in Behavioral Neuroscience·Sean C Godar, Marco Bortolato
Jan 11, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Manali DasKanchan Mukhopadhyay

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