Identification of a broadly active phage lytic enzyme with lethal activity against antibiotic-resistant Enterococcus faecalis and Enterococcus faecium

Journal of Bacteriology
Pauline YoongV A Fischetti

Abstract

Enterococcus faecalis and Enterococcus faecium infections are increasingly difficult to treat due to high levels of resistance to antibiotics. PlyV12, a bacteriophage lytic enzyme, was isolated and shown to effectively kill both E. faecalis and E. faecium (including vancomycin-resistant strains), as well as other human pathogens. We propose its development and use as an alternative therapeutic tool.

References

Oct 1, 1975·Journal of Clinical Microbiology·T CaprioliS S Kasatiya
Jan 1, 1990·Clinical Microbiology Reviews·B E Murray
Oct 1, 1994·Clinical Microbiology Reviews·B D JettM S Gilmore
Jun 1, 1994·The Journal of Antimicrobial Chemotherapy·A P Johnson
Jul 1, 1997·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·R LópezJ L García
Mar 9, 2000·Trends in Microbiology·I YoungW D Roof
Jul 25, 2000·Clinical Microbiology Reviews·M W Cunningham
Oct 12, 2000·Clinical Microbiology Reviews·Y CetinkayaC G Mayhall
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·D NelsonV A Fischetti
Aug 2, 2001·Nature Biotechnology·V A Fischetti
Aug 23, 2002·Nature·Raymond SchuchVincent A Fischetti
May 3, 2003·Annals of the New York Academy of Sciences·Vincent A Fischetti
Oct 24, 2003·Infection and Immunity·Jutta M LoefflerVincent A Fischetti

❮ Previous
Next ❯

Citations

Dec 13, 2006·Nature Biotechnology·Vincent A FischettiRaymond Schuch
Sep 11, 2012·Nature Medicine·Lauren Gravitz
Apr 7, 2012·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Daniela ProençaCarlos São-José
Mar 22, 2012·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Sofia FernandesCarlos São-José
Apr 6, 2013·The Journal of Antimicrobial Chemotherapy·Yang ShenDaniel C Nelson
Sep 9, 2010·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Justyna E KorczynskaEdward J Taylor
Jan 26, 2011·Antimicrobial Agents and Chemotherapy·Soo Youn JunSang Hyeon Kang
Dec 24, 2004·Antimicrobial Agents and Chemotherapy·Qi ChengVincent A Fischetti
Apr 18, 2013·PloS One·Raymond SchuchVincent A Fischetti
Jan 12, 2013·Current Protein & Peptide Science·Zuzanna Drulis-KawaRob Lavigne
Oct 4, 2012·Future Microbiology·Mathias SchmelcherMartin J Loessner
Feb 23, 2013·International Journal of Microbiology·Mark FentonAidan Coffey
Apr 18, 2014·Journal of Industrial Microbiology & Biotechnology·Feng HanMuhammad Naseem Khan
May 30, 2014·The Journal of Antimicrobial Chemotherapy·Tania Mareike ViertelHans-Peter Horz
Nov 12, 2013·Applied and Environmental Microbiology·Hyun Sung LeeSang Ho Choi
Sep 21, 2012·Critical Reviews in Microbiology·Lorena Rodríguez-RubioPilar García
Jun 7, 2005·Expert Opinion on Emerging Drugs·Florian M E WagenlehnerKurt G Naber
Mar 4, 2011·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Jenny Fernebro
Aug 7, 2009·Medical Hypotheses·Jan Borysowski, Andrzej Górski
Oct 23, 2008·Journal of Biotechnology·Salim ManoharadasUdo Bläsi
Oct 2, 2007·Current Opinion in Microbiology·Juan A HermosoPedro García
Jul 4, 2009·Oral Microbiology and Immunology·R H StevensA L Delisle
Jan 3, 2013·Biotechnology Journal·Barbara ThallingerGeorg M Guebitz
Dec 16, 2006·Journal of Biochemical and Biophysical Methods·Yves BriersKirsten Hertveldt
Jan 18, 2006·European Urology·Florian M E Wagenlehner, Kurt G Naber
Nov 1, 2005·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Shigenobu MatsuzakiShosuke Imai
Aug 30, 2005·Trends in Microbiology·Vincent A Fischetti
Jun 28, 2005·Current Opinion in Microbiology·Martin J Loessner
Oct 7, 2015·Bacteriophage·Dwayne R Roach, David M Donovan
May 7, 2009·FEMS Microbiology Reviews·Sarah O'FlahertyAidan Coffey
Jul 1, 2011·Bacteriophage·Vincent A Fischetti
Feb 18, 2011·Bioengineered Bugs·Mark FentonAidan Coffey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.