PMID: 164029Jan 1, 1975Paper

Identification of a calcium-binding protein as a calcium-dependent regulator of brain adenylate cyclase

Proceedings of the National Academy of Sciences of the United States of America
C O BrostromD J Wolff

Abstract

An activating factor of adenylate cyclase (EC 4.6.1.1) HAS BEEN OBTAINED FROM DETERGENT-DISPERSED PREPARATIONS OF PORCINE CEREBRAL CORTEX BY COLUMN CHROMATOGRAPHY ON ECTEOLA-cellulose. The factor was identified by acrylamide gel electrophoresis and by enzyme activation studies as the Ca2+-binding protein that regulates the activity of a brain cyclic nucleotide phosphodiesterase. This Ca2+-binding protein confers a Ca2+-dependent activation upon the adenylate cyclase, which is reversed by the subsequent addition of egta in excess of the free Ca2+. It is proposed that this Ca2+-dependent regulator controls enzymatic activities responsible for the synthesis of adenosine 3':5'-monophosphate and for the hydrolysis of guanosine 3':5'-monophosphate.

References

Jun 6, 1969·Biochemical and Biophysical Research Communications·H P Bär, O Hechter
Aug 28, 1972·Biochimica Et Biophysica Acta·L S Bradham
Jan 1, 1973·Progress in Biophysics and Molecular Biology·M W Bitensky, R E Gorman
Jun 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·R Kram, G M Tomkins
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·S KakiuchiK Uenishi
Dec 1, 1972·Journal of Neurochemistry·D J WolffF L Siegel

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Citations

Jan 1, 1995·Archives of Insect Biochemistry and Physiology·N A GrangerR Ebersohl
Jan 1, 1976·Journal of Supramolecular Structure·R A JohnsonS J Pilkis
Jan 1, 1978·Journal of Supramolecular Structure·M Vaughan, J Moss
Jul 30, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·R H RothP M Salzman
Nov 3, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·H Glossmanm
Mar 31, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E CostaP Uzunov
Jul 27, 1994·Molecular and Cellular Biochemistry·M S Nijjar, B Grimmelt
Jun 1, 1980·Neurochemical Research·F Vargas, A Guidotti
Jul 1, 1983·Canadian Anaesthetists' Society Journal·M P Walsh
Nov 23, 1979·Biochimica Et Biophysica Acta·B E Miller, F R Butcher
Nov 2, 1993·Biochemical Pharmacology·D M Kirkham, J M Henley
Sep 15, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·A J MacphersonT J Peters
Mar 1, 1992·Developmental Biology·G E Kovalick, K Beckingham
Dec 15, 1978·European Journal of Pharmacology·C LugnierJ C Stoclet
Jan 1, 1984·The International Journal of Biochemistry·M Landt, J M McDonald
Jan 1, 1984·The International Journal of Biochemistry·F C Knoop, D D Thomas
Apr 15, 1977·Life Sciences·D H Ross, H L Cardenas
Jan 1, 1980·Advances in Enzyme Regulation·T D ChrismanE G Krebs
Jan 1, 1983·Advances in Enzyme Regulation·S M DudkinE S Severin
Jan 1, 1981·Neuroscience and Biobehavioral Reviews·R D Myers, D H Ross
Jan 1, 1981·Pharmacology & Therapeutics·V M WiegantW H Gispen
Jan 1, 1987·Pharmacology & Therapeutics·G B RosenbergD R Storm
Jan 1, 1989·Pharmacology & Therapeutics·M L VeiglW D Sedwick
Feb 1, 1993·Trends in Pharmacological Sciences·D M Cooper, G Brooker
Nov 1, 1986·Neurobiology of Aging
Jan 1, 1988·Comparative Biochemistry and Physiology. A, Comparative Physiology·P M Janssens

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