PMID: 9187538Feb 1, 1997Paper

Identification of a CG/LH binding site in two strains of Mycobacterium vaccae

Endocrine Research
D T CarrellW D Odell

Abstract

We have previously reported the presence of a chorionic gonadotropin-like (CG-like) protein in the bacterium Xanthomonas maltophilia (X. maltophilia). We have also shown that X. maltophilia possesses a unique binding site for the native ligand and hCG, but not for human luteinizing hormone (hLH), and that binding of the native ligand or hCG to the receptor causes changes in the growth rates of culturing X. maltophilia. In this study we have characterized a CG/LH binding site in two strains of Mycobacterium vaccae. The binding site is specific for hCG and hLH, and Scatchard analysis reveals a biphasic, high affinity binding pattern. This is the second identified bacterial species to possess a CG-specific binding site.

References

Mar 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·N D Richert, R J Ryan
Feb 1, 1990·Endocrine Reviews·S D GharibW W Chin
Jan 29, 1993·Biochemical and Biophysical Research Communications·S GroverW D Odell

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Citations

Aug 19, 2000·Infection and Immunity·J M Spence, V L Clark
Sep 12, 2003·Experimental Biology and Medicine·Jeffrey G Edwards, William D Odell

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