Identification of a circulatory and oocytic avian apolipoprotein D

Molecular Reproduction and Development
A V VieiraP M Vieira

Abstract

Apolipoprotein D (apo D) is an unusual apolipoprotein with respect to structure and sites of synthesis. It has been identified in the circulatory system of certain mammals, but its physiological role remains poorly understood. In this report, it is shown that apo D is not exclusively a mammalian apolipoprotein, and evidence is presented which suggests a novel function for this protein during oogenesis in the chicken. The avian apo D which we identify has the same molecular mass (29 kDa) as the human protein and also associates preferentially with the plasma lipoprotein fraction. In addition to the 29 kDa avian apo D species, an immunoreactive 24 kDa protein is observed in chicken serum. The chicken apo D (along with the 24 kDa species) is also demonstrated to be present in the yolk of the rapidly growing chicken oocyte, a cell with high endocytic activity. Clathrin-coated vesicles from chicken oocytes, which we have previously shown to contain specific lipoproteins along with their oocytic receptors (Bujo et al., 1994: EMBO J 13:5165-5175), also contain chicken apo D. Thus, apo D represents a novel candidate for plasma-to-oocyte transport of lipids and/or their mobilization during embryogenesis in oviparous species.

References

Jan 1, 1991·Progress in Lipid Research·P K WeechE Rassart
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J NimpfW J Schneider
Sep 1, 1987·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S Pervaiz, K Brew
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P K NandiH Edelhoch
Feb 17, 1995·The Journal of Biological Chemistry·A V VieiraW J Schneider
Jun 1, 1993·Cell and Tissue Research·X ShenW J Schneider

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Citations

Aug 6, 2002·General and Comparative Endocrinology·Yu Yao, Amandio Vieira
Nov 4, 2000·Biochimica Et Biophysica Acta·E RassartR Milne
Sep 3, 2009·Reproductive Biology and Endocrinology : RB&E·Sonia Do CarmoEric Rassart
Dec 8, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·María D GanforninaSalvador Martínez
May 5, 2007·Biochimica Et Biophysica Acta·Sonia Do CarmoEric Rassart
Nov 30, 2007·Proteomics·Karlheinz Mann, Matthias Mann
Apr 29, 2015·The Journal of Biological Chemistry·Ouafa NajybEric Rassart
Jun 20, 2020·Gene·Eric RassartCatherine Mounier
Oct 26, 2021·Frontiers in Physiology·Diego Sanchez, Maria D Ganfornina

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