Identification of a cis-acting element within the herpesvirus saimiri ORF 6 promoter that is responsive to the HVS.R transactivator

The Journal of General Virology
Adrian WhitehouseD M Meredith

Abstract

We have previously demonstrated that two distinct transcripts are produced from ORF 50, the major transcriptional activating gene of herpesvirus saimiri. The products of these transcripts trans-activate the delayed-early ORF 6 promoter, though to different degrees. Deletion analysis demonstrated that the ORF 50 responsive elements are contained in a 132 bp fragment situated 127-259 bp from the transcription initiation site within the ORF 6 promoter. This fragment conferred ORF 50-responsiveness on an enhancerless simian virus 40. Gel retardation analysis further mapped the responsive elements to a 38 bp fragment.

Citations

Nov 21, 2007·Veterinary Research Communications·F M Frame, R G Dalziel
Sep 25, 2004·Journal of Cellular Physiology·Alexander Y Tsygankov
Apr 21, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H Fickenscher, B Fleckenstein
Feb 22, 2005·The Journal of General Virology·Matthew S WaltersAdrian Whitehouse
Jun 29, 2001·Journal of Comparative Pathology·L J CoulterH W Reid

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