PMID: 11924914Apr 2, 2002Paper

Identification of a clinical-grade maturation factor for dendritic cells

Journal of Immunotherapy
Claire BoccaccioAlessandra Nardin

Abstract

Dendritic cells (DC) are essential for the generation of primary adaptive immune responses, but their full immunostimulatory capacities are only reached upon maturation. The authors compared several clinical-grade adjuvants of bacterial origin to determine their ability to induce phenotypic and functional maturation of monocyte-derived DC (Dendritophages, Dphi; IDM, Paris, France) differentiated with granulocyte-macrophage colony-stimulating factor and interleukin-13 in single-use cell processors (VacCell; IDM, Paris, France). Monophosphoryl lipid A, Mycobacterium bovis bacillus Calmette-Guerin, and Ribomunyl (Pierre Fabre Medicament, Boulogne, France) all appeared able to provide the signal necessary to initiate Dphi maturation. However, only Ribomunyl (Pierre Fabre Medicament) (containing membrane and ribosomal fractions from four bacterial strains) allowed the authors to obtain a significant enhancement of allostimulatory abilities and cytokine production by Dphi in the absence of active cellular infection. Addition of interferon-gamma (IFN-gamma) to Ribomunyl resulted in more pronounced upregulation of CD83, major histocompatibility complex class I, and B7 molecules by Dphi. Moreover, the IFN-gamma addition modulated their ...Continue Reading

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Citations

Jun 1, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Véronique QuillienLouis Toujas
Sep 28, 2005·Cancer Immunology, Immunotherapy : CII·Margarita SalcedoThierry Velu
Jul 13, 2004·Vaccine·Radek SpisekJirina Bartunkova
Apr 22, 2006·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Pierre Portalès, Jacques Clot
Mar 1, 2009·Immunotherapy·Thomas SimonMarc Grégoire
Dec 4, 2013·Immunology and Cell Biology·Ke PanJian-chuan Xia
Jan 27, 2006·European Journal of Pharmacology·Wojciech FeleszkoEckard Hamelmann
Jan 26, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Fabien LoisonDenis Michel
Jun 26, 2007·Journal of Immunotherapy·Chiara NapoletanoMarianna Nuti
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Aug 6, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew KaiserAlessandra Nardin
Dec 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thierry LesimpleVéronique Quillien

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