PMID: 5165796Oct 1, 1971Paper

Identification of a congenital defect of factor VII in a colony of beagle dogs: the clinical use of the plasma

Journal of Clinical Pathology
L PollerW Thomas

Abstract

A severe, pure deficiency of factor VII has been defined in haematological and biochemical terms in the Alderley Park colony of beagle dogs. By modification of the conventional factor VII assay to improve its specificity an apparent low activity of between 1 and 2.5% of the normal beagle has been found. When this plasma is used as a substrate for factor VII assays it compares well with human factor VII-deficient plasma in the measurement of both raised and depressed factor VII activity. It also appears to be a valuable reagent in the quality control of tissue thromboplastin extracts.

References

Jan 1, 1970·British Journal of Haematology·R Garner, D M Conning
Apr 13, 1968·British Medical Journal·L Poller, J M Thomson
Jul 27, 1968·British Medical Journal·L PollerJ M Thomson
Feb 22, 1969·British Medical Journal·L PollerC M Priest
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Citations

Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·N W Spurling
Jan 1, 1988·Comparative Biochemistry and Physiology. A, Comparative Physiology·N W Spurling
Oct 27, 2004·The Veterinary Journal·Patricia A Gentry
Oct 17, 2003·Contraception·United Nations Development Programme/United Nations Population Fund/World Health Organization/World Bank Special Programme o
Jul 1, 1972·British Journal of Haematology·N W SpurlingT Pilling
Mar 1, 1975·British Journal of Haematology·I W DymockJ M Thomson
Nov 1, 1984·Archives of Disease in Childhood·D I Evans, I B Sardharwalla
Jan 24, 1976·British Medical Journal·M AylwardP Rees
Nov 1, 1976·Journal of Clinical Pathology·G GreenI W Dymock
Feb 1, 1981·British Journal of Haematology·Z S LatalloL Poller
Jan 1, 1987·Clinical and Laboratory Haematology·K P SchofieldL Poller
Nov 1, 1984·Archives of Disease in Childhood·J McKiernan
Apr 1, 1974·The Journal of Small Animal Practice·N W SpurlingT Pilling
Aug 1, 1980·British Journal of Obstetrics and Gynaecology·L PollerJ Coope
Feb 1, 1981·British Journal of Obstetrics and Gynaecology·C J EnglishR W Burslem
May 1, 1991·Perception & Psychophysics·V Mann, S D Soli
Jan 1, 1983·Clinical and Laboratory Haematology·J M ThomsonE B Faragher
Jan 1, 1984·Clinical and Laboratory Haematology·M Bhavnani, D I Evans

Related Concepts

Blood Coagulation Disorders
Blood Coagulation Tests
Molecular Sieve Chromatography
Dog Diseases
Canis familiaris
Factor IX
Factor V
Factor VII
Factor VII Deficiency
Factor VIII Procoagulant Activity

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