Identification of a dendrimeric heparan sulfate-binding peptide that inhibits infectivity of genital types of human papillomaviruses.

Antimicrobial Agents and Chemotherapy
Manuela DonalisioDavid Lembo

Abstract

Peptide dendrimers consist of a peptidyl branching core and/or covalently attached surface functional units. They show a variety of biological properties, including antiviral activity. In this study, a minilibrary of linear, dimeric, and dendrimeric peptides containing clusters of basic amino acids was evaluated for in vitro activity against human papillomaviruses (HPVs). The peptide dendrimer SB105-A10 was found to be a potent inhibitor of genital HPV types (i.e., types 16, 18, and 6) in pseudovirus-based neutralization assays. The 50% inhibitory concentration was between 2.8 and 4.2 μg/ml (0.59 and 0.88 μM), and no evidence of cytotoxicity was observed. SB105-A10 interacts with immobilized heparin and with heparan sulfates exposed on the cell surface, most likely preventing virus attachment. The findings from this study indicate SB105-A10 to be a leading candidate compound for further development as an active ingredient of a topical microbicide against HPV and other sexually transmitted viral infections.

References

Oct 1, 1991·Current Opinion in Cell Biology·J D Esko
Aug 1, 1988·Journal of Virological Methods·R PauwelsE De Clercq
Aug 14, 1986·Nature·D S GoldfarbR D Kornberg
Feb 1, 1993·AIDS Research and Human Retroviruses·M PatelM A Norcross
Jan 1, 1995·Critical Reviews in Biochemistry and Molecular Biology·S ErnstR Sasisekharan
Aug 8, 1998·Journal of Virology·A P Byrnes, D E Griffin
Aug 22, 2000·Antimicrobial Agents and Chemotherapy·N BourneD I Bernstein
Oct 12, 2000·The Journal of Biological Chemistry·M TyagiM Giacca
Jan 11, 2001·Journal of Virology·T GiroglouM Sapp
Apr 17, 2001·The Journal of Biological Chemistry·M RusnatiM Presta
Aug 24, 2001·The Journal of Clinical Investigation·D Shukla, P G Spear
Sep 1, 2001·Biochimie·D Spillmann
Jun 20, 2002·Journal of Biotechnology·Kristen Sadler, James P Tam
Nov 20, 2002·Sexually Transmitted Diseases·Lisa E Manhart, Laura A Koutsky
Dec 10, 2002·Current Opinion in Chemical Biology·Mary J Cloninger
Jun 17, 2003·Journal of the National Cancer Institute. Monographs·F Xavier Bosch, Silvia de Sanjosé
Dec 3, 2003·Journal of Virology·Saeed Shafti-KeramatReinhard Kirnbauer
Dec 25, 2003·Journal of Virology·Christopher B BuckJohn T Schiller
Jan 23, 2004·Chemical Society Reviews·Ulrik Boas, Peter M H Heegaard
May 29, 2004·Trends in Microbiology·Susana López, Carlos F Arias
Jun 9, 2004·Virology·Ethel-Michele de VilliersHarald zur Hausen
Oct 1, 2005·Journal of Peptide Science : an Official Publication of the European Peptide Society·Petr NiederhafnerJan Jezek
Oct 29, 2005·Journal of Virology·Cornelis A M de HaanPeter J M Rottier
Dec 15, 2005·Methods in Molecular Medicine·Christopher B BuckJohn T Schiller
Jul 15, 2006·PLoS Pathogens·Christopher B BuckJohn T Schiller
Aug 25, 2006·Journal of Virology·Heidi BarthThomas F Baumert
Mar 3, 2007·Nature·Erika Check
May 4, 2007·The Journal of Clinical Investigation·Karen Honey
Mar 28, 2008·Journal of Virology·Christopher B BuckBenes L Trus
Oct 16, 2009·The Journal of Investigative Dermatology·Damjan S Nikolic, Vincent Piguet

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Citations

Jan 16, 2014·Indian Journal of Virology : an Official Organ of Indian Virological Society·Vinay Ganeshrao JoshiSatish Kumar
May 21, 2011·The Journal of Biological Chemistry·Vaibhav TiwariDeepak Shukla
May 18, 2011·Antimicrobial Agents and Chemotherapy·Anna LuganiniGiorgio Gribaudo
Aug 2, 2012·Antimicrobial Agents and Chemotherapy·Manuela DonalisioDavid Lembo
Jan 11, 2013·Journal of Virology·Beatriz SalvadorGraham Simmons
Feb 23, 2013·International Journal of Nanomedicine·Rossella TaralloMarcus Weck
Dec 4, 2012·Expert Review of Anti-infective Therapy·Yanchen Zhou, Graham Simmons
Aug 2, 2012·Pharmacology & Therapeutics·Domenica Musumeci, Daniela Montesarchio
May 17, 2011·Pharmacology & Therapeutics·Beatrice MercorelliArianna Loregian
Jul 5, 2012·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Joanna LazniewskaTeresa Gabryelak
Apr 21, 2011·Angewandte Chemie·Ana C RodrigoDavid K Smith
Mar 18, 2011·Reviews in Medical Virology·Kevin K AriënGuido Vanham
Mar 23, 2012·Journal of Peptide Science : an Official Publication of the European Peptide Society·Leticia FernándezIsabel Haro
Apr 5, 2013·Medicinal Research Reviews·Marta Correia-da-SilvaMadalena M M Pinto
Jan 22, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Natalia BarkalinaKevin Coward
Jul 31, 2012·Carbohydrate Polymers·Shuqin HanTakashi Yoshida
Mar 13, 2012·Biophysical Journal·Mariano A ScorciapinoAndrea C Rinaldi
Mar 4, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ksenia V KozhikhovaMusa R Khaitov
Mar 10, 2017·International Journal of Molecular Sciences·Mariano A ScorciapinoAndrea C Rinaldi
Nov 19, 2020·Journal of Microbiology and Biotechnology·Hee-Jung LeeYoung Bong Kim
Mar 7, 2021·International Journal of Molecular Sciences·Sinead CarseGeorgia Schäfer
Sep 27, 2019·Chemical Reviews·Rachit SapraV Haridas
Oct 3, 2021·Advanced Healthcare Materials·Agnès KurokiYi Yan Yang
Aug 16, 2019·Life Sciences·Fatemeh Sadat Tabatabaei MirakabadJavad Ranjbari

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