PMID: 8951793Oct 1, 1996Paper

Identification of a developmentally regulated protein tyrosine phosphatase in embryonic stem cells that is a marker of pluripotential epiblast and early mesoderm

Mechanisms of Development
K LeeA Smith

Abstract

A sensitive RT-PCR display technique was used to examine the expression of protein tyrosine phosphatases (PTPs) during the differentiation of mouse embryonic stem (ES) cells. The majority of PTPs are expressed constitutively but one is present only in undifferentiated ES cells. This PTP was cloned and named ES cell phosphatase (ESP). ESP mRNA is detectable in oocytes and throughout early mouse embryo development. At early egg cylinder stages, transcripts are localised in the pluripotential epiblast. As gastrulation commences, however, epiblast expression is lost. Transcripts are present transiently in newly formed embryonic mesoderm. These data suggest that this transmembrane signaling molecule is associated with developmental lability in early embryogenesis.

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Citations

Nov 15, 2011·Annual Review of Physiology·Gerard Karsenty, Franck Oury
Apr 17, 2002·The Journal of Urology·Maria Rosa MaduroDolores J Lamb
Feb 7, 2015·The Journal of Endocrinology·K J OldknowC Farquharson
May 24, 2011·Trends in Endocrinology and Metabolism : TEM·Franck Oury, Gerard Karsenty
Aug 29, 2014·Arquivos brasileiros de endocrinologia e metabologia·Leila C B ZanattaCarolina A M Kulak
Mar 26, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·R DacquinA Smith
Aug 19, 2005·The EMBO Journal·Gilles DoumontJean-Christophe Marine
Jun 28, 2002·The Journal of Biological Chemistry·Melany JacksonGerard J Graham
Jul 30, 2005·Journal of Cellular Biochemistry·Katherine R Schiller, Laura J Mauro
Dec 11, 2019·Cell Death & Disease·Seokheon HongShin Jung Kang
Oct 16, 2020·International Journal of Molecular Sciences·Toshihisa Komori
Jun 15, 2020·Journal of Oral Biosciences·Toshihisa Komori

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