PMID: 9557749Apr 29, 1998Paper

Identification of a full-length cDNA for an endogenous retrovirus of miniature swine

Journal of Virology
D E AkiyoshiJ A Fishman

Abstract

Endogenous retroviruses of swine are a concern in the use of pig-derived tissues for xenotransplantation into humans. The nucleotide sequence of porcine endogenous retrovirus taken from lymphocytes of miniature swine (PERV-MSL) has been characterized. PERV-MSL is a type C retrovirus of 8,132 bp with the greatest nucleic acid sequence identity to gibbon ape leukemia virus and murine leukemia virus. Constitutive production of PERV-MSL RNA has been detected in normal leukocytes and in multiple organs of swine. The copy numbers of full-length PERV sequences per genome (approximately 8 to 15) vary among swine strains. The open reading frames for gag, pol, and env in PERV-MSL have over 99% amino acid sequence identity to those of Tsukuba-1 retrovirus and are highly homologous to those of endogenous retrovirus of cell line PK15 (PK15-ERV). Most of the differences in the predicted amino acid sequences of PK15-ERV and PERV-MSL are in the SU (cell attachment) region of env. The existence of these PERV clones will enable studies of infection by endogenous retroviruses in xenotransplantation.

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Citations

Feb 3, 1999·Annals of the New York Academy of Sciences·J A Fishman
Jan 8, 2000·Clinical and Experimental Pharmacology & Physiology·L E Chapman
Nov 17, 2001·Journal of Virology·C HerringL Scobie
Mar 12, 2002·Journal of Cardiac Surgery·J A Fishman
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Aug 20, 2002·The Journal of General Virology·Birke BartoschYasuhiro Takeuchi
Dec 25, 2003·Journal of Virology·Ching-Hung Shen, Lisa A Steiner
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Feb 14, 2009·Molecules and Cells·Jae-Won HuhHeui-Soo Kim
Aug 19, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Jan-Henning FrühaufAugustinus Bader
Nov 26, 2009·Journal of Veterinary Science·Hyoung Joon MoonBong Kyun Park
Feb 11, 2011·Journal of Virology·Eva DörrschuckRalf R Tönjes
Mar 1, 2009·Indian Journal of Microbiology·M Suji Prabha, Susan Verghese
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Jul 21, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Y MeijeJ A Fishman
Sep 8, 2007·Archives of Virology·J-W HuhH-S Kim

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