PMID: 9375361Nov 1, 1996Paper

Identification of a functional Gs protein in Euglena gracilis

Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology
M E Torres-MárquezA Vega-Segura


We found a Gs protein coupled to adenylyl cyclase in a free-living protist, Euglena gracilis. This Gs protein of approximately 42 kDa is substrate for cholera toxin and is recognized by an antibody against the C-terminal decapeptide of Gs. Furthermore, this protein is coupled to adenylyl cyclase, as shown by: (a) the activation of the enzyme by GTP-analogues and (b) the effect of cholera toxin on cAMP accumulation in intact cells and the continuous activation of adenylyl cyclase activity in membranes. These data indicate that the Gs-adenylyl cyclase-coupled system is already apparent in the protist kingdom.


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