PMID: 6104573May 1, 1980Paper

Identification of a glutathione conjugate of cambendazole formed in the presence of liver microsomes

Drug Metabolism and Disposition : the Biological Fate of Chemicals
D E WolfF J Wolf

Abstract

The incubation of multiply labeled (2H, 3H, 13C, 14C) cambendazole and glutathione with hepatic microsomes from phenobarbital-dosed hamsters results in the formation of polar metabolites. The major metabolite has been characterized by a variety of isotopic, spectrometric, chromatographic, and degradative/synthetic techniques as a glutathione conjugate of cambendazole in which substitution is on the 4-position of the benzimidazole nucleus. The same metabolite is produced by hepatic microsomes from the rat.

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