PMID: 6172539Jan 1, 1982Paper

Identification of a hemagglutinin-specific idiotype associated with reovirus recognition shared by lymphoid and neural cells

The Journal of Experimental Medicine
J T NepomM I Greene

Abstract

A xenogeneic antiserum raised to antireovirus immunoglobulin was used to define an idiotypic determinant present on antibodies to reovirus type 3 hemagglutinin. The same idiotype was identified on nonimmune lymphoid cells and on neuronal cells that specifically bind the hemagglutinin of type 3 reovirus. This idiotypic determinant, called Id3, is shared by (a) a monoclonal antibody to the neutralization site of hemagglutinin from type 3 reovirus; (b) BALB/c serum antibodies to the hemagglutinin of reovirus type 3; (c) R1.1, a murine thymoma cell line that binds reovirus type 3; (d) primary cultures of murine neuronal cells. The presence of an idiotype shared by antihemagglutinin antibodies and by structures on nonlymphoid cells suggests a general relationship between disparate receptors that recognize a common determinant. Furthermore, this suggests a novel approach for the study of viral receptor interactions and for analysis of mechanisms of autoimmune responses.

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Citations

Jan 1, 1989·Archives of Virology·A NathJ S Wolinsky
Jan 1, 1982·Springer Seminars in Immunopathology·P R Carnegie, I R Mackay
Sep 1, 1982·Indian Journal of Pediatrics·A K Abbas
Aug 1, 1983·Journal of Virological Methods·R C Kennedy, G R Dreesman
Nov 1, 1988·Annales De L'Institut Pasteur. Immunology·W V WilliamsM I Greene
Oct 18, 1984·The New England Journal of Medicine·Y Shoenfeld, R S Schwartz
Feb 21, 1985·The New England Journal of Medicine·A H Sharpe, B N Fields
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·H C ErtlR W Finberg
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M S CoM I Greene
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M S CoM I Greene
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C BruckM I Greene
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R Singhai, J G Levy
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R VentimigliaH M Geller
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·Y KokaiM I Greene
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J A CohenM I Greene
Feb 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J A CohenM I Greene
Jan 1, 1988·Journal of Immunoassay·M BrunnerS Chin
Jun 14, 2000·Journal of Virology·M MeiteJ P Coutelier
Feb 8, 2006·Immunologic Research·Dina Montufar-Solis, John R Klein
Dec 1, 1988·European Journal of Epidemiology·L Polonelli, G Morace
Jan 1, 1986·International Reviews of Immunology·G N Gaulton, M I Greene
Jan 1, 1986·International Reviews of Immunology·R C Kennedy, G R Dreesman
Dec 1, 1987·Immunological Reviews·M I GreeneJ A Cohen
Jan 1, 1988·Annals of the New York Academy of Sciences·V ter Meulen
Jan 1, 1988·Annals of the New York Academy of Sciences·J A CohenM I Greene
May 1, 1989·International Journal of Dermatology·A R Ahmed, G B Rosen
Jan 1, 1982·Annals of the New York Academy of Sciences·A TominagaM I Greene
Jan 1, 1985·Journal of Cellular Biochemistry·G GaultonM I Greene

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