Identification of a herpes simplex labialis susceptibility region on human chromosome 21

The Journal of Infectious Diseases
Maurine R HobbsJohn D Kriesel

Abstract

Most of the United States population is infected with either herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2, or both. Reactivations of HSV-1 infection cause herpes simplex labialis (HSL; cold sores or fever blisters), which is the most common recurring viral infection in humans. To investigate the possibility of a human genetic component conferring resistance or susceptibility to cold sores (i.e., a HSL susceptibility gene), we conducted a genetic linkage analysis that included serotyping and phenotyping 421 individuals from 39 families enrolled in the Utah Genetic Reference Project. Linkage analysis identified a 2.5-Mb nonrecombinant region of interest on the long arm of human chromosome 21, with a multipoint logarithm of odds score of 3.9 noted near marker abmc65 (D21S409). Nonparametric linkage analysis of the data also provided strong evidence for linkage (P = .0005). This region of human chromosome 21 contains 6 candidate genes for herpes susceptibility. The development of frequent cold sores is associated with a region on the long arm of human chromosome 21. This region contains several candidate genes that could influence the frequency of outbreaks of HSL.

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Citations

Jul 26, 2008·The Journal of Infectious Diseases·Ruth Itzhaki, Matthew Wozniak
Nov 1, 2011·The Journal of Infectious Diseases·Anthony L Cunningham, David Booth
Sep 19, 2008·Journal of Virology·Aziz Alami ChentoufiLbachir BenMohamed
Jan 16, 2013·Clinical & Developmental Immunology·Aziz Alami Chentoufi, Lbachir Benmohamed
Apr 2, 2013·The Journal of Dermatological Treatment·Vanessa N RichardsonSteven R Feldman
Aug 31, 2017·Annual Review of Genetics·Adam D KenneyJacob S Yount
Jan 18, 2008·The Journal of Infectious Diseases·David M Koelle, Tracy L Bergemann
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Dec 27, 2018·Current Opinion in Infectious Diseases·Anjali Patel, Rajul Patel
Oct 16, 2016·Journal of Neurovirology·Robert J DanaherCraig S Miller

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