Identification of a Human Clonogenic Progenitor with Strict Monocyte Differentiation Potential: A Counterpart of Mouse cMoPs

Immunity
Shunsuke KawamuraToshiaki Ohteki

Abstract

Monocytes give rise to macrophages and dendritic cells (DCs) under steady-state and inflammatory conditions, thereby contributing to host defense and tissue pathology. A common monocyte progenitor (cMoP) that is strictly committed to the monocyte lineage has been recently identified in mice. Here, we identified human cMoPs as a CLEC12A(hi)CD64(hi) subpopulation of conventional granulocyte-monocyte progenitors (cGMPs) in umbilical cord blood and in bone marrow. Human cMoPs gave rise to monocyte subsets without showing any potential for differentiating into myeloid or lymphoid cells. Within the cGMP population, we also identified revised GMPs that completely lacked DC and lymphoid potential. Collectively, our findings expand and revise the current understanding of human myeloid cell differentiation pathways.

Citations

Aug 4, 2018·Immunotherapy·Ryota TamuraHikaru Sasaki
Sep 25, 2018·International Immunology·Shunsuke Kawamura, Toshiaki Ohteki
Feb 19, 2019·Journal of Leukocyte Biology·Claire E OlingyCatherine C Hedrick
Apr 27, 2019·Annual Review of Immunology·Prakash Babu NarasimhanCatherine C Hedrick
Jan 17, 2019·Annual Review of Immunology·Kevin BasslerJoachim L Schultze
Oct 23, 2019·Frontiers in Immunology·Patrick Günther, Joachim L Schultze
Jun 13, 2020·Journal of Leukocyte Biology·Lindsey E PadgettClaire E Olingy
Dec 24, 2018·Nature Communications·Dorothée Selimoglu-BuetEric Solary
Aug 6, 2019·Frontiers in Immunology·Anja A WolfHelen S Goodridge
Apr 8, 2020·Frontiers in Immunology·Charles Caër, Mary Jo Wick
Sep 11, 2020·Nature Reviews. Immunology·David A AndersonKenneth M Murphy
May 10, 2018·Scientific Reports·Megha RajasekharJohn E J Rasko
Aug 14, 2019·Frontiers in Immunology·Nadine S JahchanMatthew F Krummel
Dec 4, 2019·Frontiers in Immunology·Amit A Patel, Simon Yona
Jan 16, 2021·Trends in Immunology·Amy RobinsonJeffrey W Pollard
Mar 26, 2021·Frontiers in Immunology·Jean-Louis PalgenAnne-Sophie Beignon
Apr 3, 2021·Nature Communications·Anne Kathrin LössleinPhilipp Henneke
Jun 16, 2021·The Journal of Experimental Medicine·Aaron J WilkCatherine A Blish
Jun 17, 2021·International Immunology·Toshiaki OhtekiNobuyuki Onai
Jun 27, 2021·The American Journal of Surgical Pathology·Samuel G KatzMina L Xu
Jul 8, 2021·Nature Reviews. Immunology·Catherine C Hedrick, Ilaria Malanchi
Dec 3, 2021·Current Opinion in Hematology·Abhishek Dhawan, Eric Padron

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