Identification of a Human SOCS1 Polymorphism That Predicts Rheumatoid Arthritis Severity.

Frontiers in Immunology
Amalia LamanaMario Mellado

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by an autoimmune response in the joints and an exacerbation of cytokine responses. A minority of patients with RA experience spontaneous remission, but most will show moderate/high disease activity, with aggressive joint damage and multiple systemic manifestations. There is thus is a great need to identify prognostic biomarkers for disease risk to improve diagnosis and prognosis, and to inform on the most appropriate therapy. Here we focused on suppressor of cytokine signaling 1 (SOCS1), a physiological negative regulator of cytokines that modulates cell activation. Using four independent cohorts of patients with arthritis, we characterized the correlation between SOCS1 mRNA levels and clinical outcome. We found a significant inverse correlation between SOCS1 mRNA expression and disease activity throughout the follow-up of patients with RA. Lower baseline SOCS1 levels were associated with poorer disease control in response to methotrexate and other conventional synthetic disease-modifying anti-rheumatic drugs in early arthritis, and to rituximab in established (active) RA. Moreover, we identified several single nucleotide polymorphisms in the SOCS1 gene t...Continue Reading

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Datasets Mentioned

BETA
SCV000999906

Methods Mentioned

BETA
density gradient centrifugation
chip
genotyping
Assay
in vitro transcription
transfection

Software Mentioned

PLINK
Graphpad Prism
Haploview
Stata

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