Identification of a leukemic counterpart of the plasmacytoid dendritic cells.

Blood
Laurence ChaperotM C Jacob

Abstract

This work aims to demonstrate that CD4(+)CD56(+) malignancies arise from transformed cells of the lymphoid-related plasmacytoid dendritic cell (pDC) subset. The analysis of malignant cells from 7 patients shows that in all cases, like pDCs, leukemic cells are negative for lineage markers CD3, CD19, CD13, CD33, and CD11c but express high levels of interleukin-3 receptor alpha chain (IL-3Ralpha), HLA-DR, and CD45RA. Tumor cells produce interferon-alpha in response to influenza virus, while upon maturation with IL-3 they become a powerful inducer of naive CD4(+) T-cell proliferation and promote their T-helper 2 polarization. As pDCs, leukemic cells also express pre-Talpha and lambda-like 14.1 transcripts, arguing in favor of a lymphoid origin. In addition, malignant cells express significant levels of CD56 and granzyme B. Overall, those observations suggest that CD4(+)CD56(+) leukemic cells could represent the malignant counterpart of pDCs, both of which are closely related to B, T, and NK cells.

Citations

Aug 5, 2003·International Journal of Hematology·Kazuo Oshimi
Nov 15, 2002·International Journal of Hematology·Kazuo Oshimi
Nov 9, 2012·Annals of Hematology·Ho Jung AnCheolwon Suh
Oct 14, 2004·Virchows Archiv : an International Journal of Pathology·Eva GeissingerThomas Rüdiger
Oct 18, 2005·Virchows Archiv : an International Journal of Pathology·Young-Hyeh KoYoonjung Kim
Mar 7, 2009·Journal of Clinical Immunology·Wei Cao
Jul 20, 2002·Leukemia Research·Roberto P FalcãoNorma T Foss
Dec 14, 2002·Human Immunology·Francine BrièreElizabeth E M Bates
Dec 14, 2002·Human Immunology·Pia Björck
Apr 26, 2002·Current Opinion in Immunology·Marco ColonnaMarina Cella
Nov 1, 2003·Best Practice & Research. Clinical Haematology·Tomasz SzczepańskiJacques J M van Dongen
Oct 6, 2009·Bone Marrow Transplantation·P KaloyannidisI Sakellari
Sep 26, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David L JayeDan Jones
Oct 7, 2008·Oncogene·N ChaputL Zitvogel
Sep 26, 2003·The American Journal of Surgical Pathology·Kennosuke KarubeMasahiro Kikuchi
Oct 25, 2003·The American Journal of Surgical Pathology·Fabio FacchettiClaudio Doglioni
Sep 15, 2005·The American Journal of Surgical Pathology·Kaaren K ReichardRichard S Larson
Nov 7, 2007·Journal of Pediatric Hematology/oncology·Ann Veronique C EguarasMa Luz U Del Rosario
May 6, 2009·Journal of Pediatric Hematology/oncology·Asahito HamaSeiji Kojima
Dec 15, 2004·Journal of Virology·Kelli McKennaNina Bhardwaj
Jun 28, 2011·Acta Haematologica·Daichi InoueTakayuki Takahashi
Jan 26, 2008·Blood·Teresa MarafiotiDavid Y Mason
Jan 30, 2009·Blood·Miriam Merad, Markus G Manz
Mar 16, 2005·International Journal of Hematology·Takahiro MaedaShimeru Kamihira
Oct 16, 2012·Haematologica·Livio PaganoUNKNOWN GIMEMA-ALWP (Gruppo Italiano Malattie EMatologiche dell'Adulto, Acute Leukemia Working Party)
Nov 17, 2010·Indian Journal of Dermatology, Venereology and Leprology·Ilkin ZindanciMelek Koc
Aug 3, 2012·Immunotherapy·Arpit BhargavaPradyumna Kumar Mishra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.