PMID: 25738365Mar 5, 2015Paper

Identification of a microRNA signature associated with risk of distant metastasis in nasopharyngeal carcinoma

Oncotarget
Jeff P BruceFei-Fei Liu

Abstract

Despite significant improvement in locoregional control in the contemporary era of nasopharyngeal carcinoma (NPC) treatment, patients still suffer from a significant risk of distant metastasis (DM). Identifying those patients at risk of DM would aid in personalized treatment in the future. MicroRNAs (miRNAs) play many important roles in human cancers; hence, we proceeded to address the primary hypothesis that there is a miRNA expression signature capable of predicting DM for NPC patients. The expression of 734 miRNAs was measured in 125 (Training) and 121 (Validation) clinically annotated NPC diagnostic biopsy samples. A 4-miRNA expression signature associated with risk of developing DM was identified by fitting a penalized Cox Proportion Hazard regression model to the Training data set (HR 8.25; p < 0.001), and subsequently validated in an independent Validation set (HR 3.2; p = 0.01). Pathway enrichment analysis indicated that the targets of miRNAs associated with DM appear to be converging on cell-cycle pathways. This 4-miRNA signature adds to the prognostic value of the current "gold standard" of TNM staging. In-depth interrogation of these 4-miRNAs will provide important biological insights that could facilitate the discov...Continue Reading

References

Feb 28, 1997·Statistics in Medicine·R Tibshirani
Mar 26, 2003·Pathology, Research and Practice·Kazuto YamazakiYasuo Ishida
Feb 26, 2004·Statistics in Medicine·Patrick Royston, Willi Sauerbrei
Apr 20, 2004·International Journal of Radiation Oncology, Biology, Physics·Wai-Man SzeKuen Chan
Jun 11, 2004·The New England Journal of Medicine·Jin-Ching LinRong-San Jiang
Apr 6, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anthony T C ChanAlex Y Chang
Oct 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kenneth W YipFei-Fei Liu
Oct 25, 2006·Nature Reviews. Cancer·George A Calin, Carlo M Croce
Dec 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sing-fai LeungAnthony T C Chan
Dec 22, 2006·American Journal of Epidemiology·Eric Vittinghoff, Charles E McCulloch
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Feb 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Paul C BoutrosIgor Jurisica
Mar 8, 2011·Trends in Molecular Medicine·Cathy A AndorferEdith A Perez
Sep 29, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B B Y MaA T C Chan
Oct 26, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hai-Yun WangJian-Yong Shao
Oct 27, 2011·PLoS Computational Biology·David VenetVincent Detours
Jan 18, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Cheng-Chang Lee, Ching-Yin Ho
Mar 8, 2012·Journal of the National Cancer Institute·Viswam S NairJohn P A Ioannidis
Apr 12, 2012·Carcinogenesis·Marilena V Iorio, Carlo M Croce
Jun 1, 2012·The Cancer Journal·Mattia BoeriGabriella Sozzi
Sep 4, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Anne W M LeeT H Lam
Oct 27, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Hong-Sheng YuLi Yu
Feb 1, 2013·PLoS Computational Biology·Andrew H BeckBenjamin Haibe-Kains
Jul 28, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Roland SeilerAchim Fleischmann
Apr 29, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Tzu-Ju ChenChien-Feng Li
May 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B B Y MaA T C Chan

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Citations

May 12, 2015·Cancer Cell International·Kaladhar B Reddy
May 31, 2017·Journal of Cellular and Molecular Medicine·Chen QuYunfei Xia
Jan 31, 2019·International Journal of Cancer. Journal International Du Cancer·Geok Wee TanLu Ping Tan
Mar 20, 2020·Expert Review of Molecular Diagnostics·Yin Lam ChuSze Chuen Cesar Wong
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeff P BruceFei-Fei Liu
Jun 28, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ursula HeilmeierThomas M Link
Mar 18, 2016·Journal of Radiation Research·Jennifer Y Y KwanFei-Fei Liu
Aug 13, 2020·The Journal of Pharmacy and Pharmacology·Vandit Shah, Jigna Shah
Sep 11, 2019·Bioinformatics·Mickaël CanouilRoderick C Slieker
Jul 2, 2021·Nature Reviews. Clinical Oncology·Kenneth C W WongAnthony T C Chan
Aug 3, 2021·Frontiers in Cell and Developmental Biology·Yunqin ChenYixue Li
Oct 16, 2021·International Journal of Clinical Oncology·Ashita GadwalPurvi Purohit

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