PMID: 11342226May 9, 2001Paper

Identification of a murine cysteinyl leukotriene receptor by expression in Xenopus laevis oocytes

Biochimica Et Biophysica Acta
J MollerupElse K Hoffmann

Abstract

We report the identification of an EST encoding a murine cysteinyl leukotriene (mCysLT) receptor. LTD4, LTC4 and LTE4 but not LTB4 or various nucleotides activated Ca2+-evoked Cl- currents in mCysLT1 expressing Xenopus laevis oocytes. The response to LTD4 was blocked by MK-571, reduced by pretreatment with pertussis toxin (PTX), and was partly dependent on extracellular Ca2+. The identified murine CysLT1 receptor differs from the hCysLT1 receptor with regard to PTX sensitivity, receptor-mediated Ca2+ influx, and antagonist sensitivity.

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Citations

Mar 27, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·E K Hoffmann, C Hougaard
Aug 29, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T M Laidlaw, J A Boyce
Jan 8, 2009·Physiological Reviews·Else K HoffmannStine F Pedersen
Mar 5, 2003·Pharmacological Reviews·Charles BrinkTakehiko Yokomizo
Nov 19, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hannah E CummingsJoshua A Boyce
Dec 20, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Else Kay Hoffmann
Apr 30, 2011·Chemical Reviews·Motonao Nakamura, Takao Shimizu

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