Identification of a myeloid intrathymic pathway of dendritic cell development marked by expression of the granulocyte macrophage-colony-stimulating factor receptor.

Blood
Virginia G de YébenesMariá L Toribio

Abstract

In this study, the finding that a significant proportion of all dendritic cells (DCs) resident in vivo in the human postnatal thymus displayed a myeloid-related phenotype prompted us to re-examine the developmental origin of thymic DCs, a cell type hitherto considered to represent a homogeneous lymphoid-derived population. We show here that these novel intrathymic DCs are truly myeloid, as they arise from CD34(+) early thymic progenitors through CD34(lo) intermediates which have lost the capacity to generate T cells, but display myelomonocytic differentiation potential. We also demonstrate that phenotypically and functionally equivalent myeloid precursors devoid of T-cell potential do exist in vivo in the postnatal thymus. Moreover, although interleukin 7 (IL-7) supports the generation of such myeloid intermediates, we show that their developmental branching from the main intrathymic T-cell pathway is linked to the up-regulation of the myelomonocytic granulocyte macrophage-colony-stimulating factor (GM-CSF) receptor, to the down-regulation of the IL-7 receptor and to the lack of pre-T-cell receptor alpha (pTalpha) gene transcriptional activation. Taken together, these data challenge the current view that the thymus is colonized...Continue Reading

References

Aug 1, 1994·The Journal of Experimental Medicine·M J SánchezJ H Phillips
Oct 1, 1993·The Journal of Experimental Medicine·Y MatsuzakiH Nakauchi
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K InabaR M Steinman
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·L J Zhou, T F Tedder
Apr 1, 1997·Immunological Reviews·R M SteinmanK Inaba
Jul 1, 1997·Immunology Today·C Ardavín
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·H R RodewaldC Haller
Feb 19, 2000·Current Opinion in Immunology·S D ReidL Adorini
Jun 3, 2000·Annual Review of Immunology·J BanchereauK Palucka
Dec 20, 2000·The Journal of Experimental Medicine·J BanchereauK Palucka
Mar 10, 2001·Blood·S VandenabeeleK Shortman
Apr 4, 2001·The Journal of Clinical Investigation·N Bendriss-VermareF Brière
Apr 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C Martinon-EgoP N Marche
May 9, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C K LeeS S Han

❮ Previous
Next ❯

Citations

Jun 11, 2005·Seminars in Immunology·Li Wu, Ken Shortman
Dec 14, 2002·Human Immunology·Bianca BlomHergen Spits
Sep 11, 2002·Seminars in Immunology·Yolanda R CarrascoMaría L Toribio
Jan 28, 2003·Trends in Immunology·Irving Goldschneider, Robert E Cone
Apr 7, 2007·Immunobiology·Nathalie SchmittNicole Israël
May 16, 2015·The International Journal of Biochemistry & Cell Biology·Ramon M RodriguezBeatriz Suarez-Alvarez
Mar 11, 2015·Immunology and Cell Biology·Víctor G MartínezAlberto Varas
Jan 24, 2004·Immunity·Carlos ArdavínCaetano Reis e Sousa
Dec 30, 2014·Nucleic Acids Research·Ramon M RodriguezCarlos Lopez-Larrea
Sep 28, 2017·The Journal of Experimental Medicine·Enrique Martín-GayoMaría L Toribio
Oct 3, 2002·Nature Reviews. Immunology·Hergen Spits
Mar 17, 2004·Cancer Control : Journal of the Moffitt Cancer Center·Marcus O Muench, Alicia Bárcena
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marina García-PeydróMaría L Toribio

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.