Identification of a naturally occurring polymorphism in the promoter region of the norepinephrine transporter and analysis in major depression

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Peter ZillBrigitta Bondy

Abstract

Disturbances in the noradrenergic neurotransmission system have been implicated in the etiology of mood disorders. The norepinephrine transporter (NET) is a main target of antidepressant action and was shown to be dysregulated in major depression. Despite the clinical and physiological significance of NET gene regulation, little is known about the transcriptional control mechanisms governing its expression. Since it is well established that affective disorders have a genetic component with many genes of small effect contributing to the genetic susceptibility of depression, the NET gene is an interesting candidate gene for affective disorders. In a search for polymorphisms or mutations in the 5' flanging region of the NET gene we sequenced approximately 1000 bp upstream of the first codon in the NET gene promoter in 100 patients with major depression and 100 healthy controls. We identified a so far unknown T --> C polymorphism 182 bp upstream of the start codon in a transcriptional relevant region. In a case control association study we investigated the newly identified T-182C polymorphism and an already known G1287A polymorphism in exon 9 of the NET gene in a sample of 193 patients with major depression and 136 healthy, non-rel...Continue Reading

Citations

Aug 7, 2013·Archives of Women's Mental Health·Julia K PinsonneaultMeir Steiner
Sep 19, 2003·Current Psychiatry Reports·Thomas W McAllister, Lanier Summerall
Oct 29, 2002·Neuroscience Letters·P G SandJ Deckert
Oct 17, 2007·Molecular Psychiatry·S López-LeónC M van Duijn
Jun 8, 2013·ILAR Journal·Eldin JašarevićCheryl S Rosenfeld
Oct 28, 2006·Annual Review of Pharmacology and Toxicology·Maureen K Hahn, Randy D Blakely
Nov 25, 2006·Kidney & Blood Pressure Research·Piotr KsiazekMonika Buraczynska
Mar 6, 2003·CNS Drugs·Dalu Mancama, Robert W Kerwin
Jan 2, 2013·Frontiers in Bioscience (Landmark Edition)·Shu MengHong Wang
Jul 4, 2008·Pharmacogenomics·Eugene Lin, Po See Chen
Jul 27, 2007·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Chuan-Chia ChangSan-Yuan Huang
Apr 3, 2012·Journal of Cardiac Failure·Jasmine A TalamehJ Herbert Patterson
Sep 6, 2006·Child and Adolescent Psychiatric Clinics of North America·Gil ZalsmanJ John Mann
Mar 6, 2015·Nordic Journal of Psychiatry·Kadri AndreEsa Leinonen
May 21, 2015·Acta Neuropsychiatrica·Jennifer Lynne PhillipsPierre Blier
Jun 3, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·A SzökeM Leboyer
Oct 24, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Carl A AndersonDouglas H R Blackwood
May 17, 2005·Medical Hypotheses·Katherine A RaymerCatherine R Price
Dec 19, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·A MéaryP M Llorca
Apr 29, 2015·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Ajeet Bhagat SinghMichael Berk
Jul 25, 2017·Clinical and Experimental Hypertension : CHE·Lin MengJingzhou Chen
Dec 19, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Vincenzo De LucaJames L Kennedy
Apr 29, 2018·International Journal of Psychiatry in Clinical Practice·Su-Xia CaoGuang-Rong Xie

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