Identification of a naturally processed T cell epitope derived from the glioma-associated protein SOX11

Cancer Letters
Marc SchmitzBernd Weigle

Abstract

The development of T cell-based immunotherapies of cancer depends on the identification of tumor-associated antigens capable of eliciting tumor-directed cytotoxic T cell responses. In malignant glioma the number of well-defined target antigens for cytotoxic T lymphocytes (CTLs) is still very limited. Recently, we demonstrated the abundant and specific overexpression of the transcription factor SOX11 in malignant glioma. Here, we describe the SOX11-derived peptide LLRRYNVAKV which is capable of inducing human leukocyte antigen-A*0201-restricted and tumor-reactive CTLs. This novel CTL epitope may serve as an attractive candidate for a T cell-based immunotherapy of glioma.

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Citations

Apr 8, 2009·Critical Reviews in Immunology·Hideho OkadaMitsugu Fujita
Jul 11, 2014·Journal of Immunology Research·Dong-Sup ChungYong-Kil Hong
Aug 16, 2014·Journal of Immunology Research·Zhe Bao WuLiang Fu Zhou
Sep 4, 2009·International Journal of Cancer. Journal International Du Cancer·Ryo UedaMasahiro Toda
Aug 30, 2008·The Journal of General Virology·Andreas O WeinzierlKarin Klingel
Apr 5, 2012·Clinical & Developmental Immunology·Xun XuMichael Schmitt
Jul 14, 2016·Expert Opinion on Biological Therapy·Neha KamranMaria G Castro
Mar 28, 2008·Immunological Reviews·Duane A MitchellJohn H Sampson

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