Identification of a neurocircuit underlying regulation of feeding by stress-related emotional responses

Nature Communications
Yuanzhong XuQingchun Tong

Abstract

Feeding is known to be profoundly affected by stress-related emotional states and eating disorders are comorbid with psychiatric symptoms and altered emotional responses. The neural basis underlying feeding regulation by stress-related emotional changes is poorly understood. Here, we identify a novel projection from the paraventricular hypothalamus (PVH) to the ventral lateral septum (LSv) that shows a scalable regulation on feeding and behavioral changes related to emotion. Weak photostimulation of glutamatergic PVH→LSv terminals elicits stress-related self-grooming and strong photostimulation causes fear-related escape jumping associated with respective weak and strong inhibition on feeding. In contrast, inhibition of glutamatergic inputs to LSv increases feeding with signs of reduced anxiety. LSv-projecting neurons are concentrated in rostral PVH. LSv and LSv-projecting PVH neurons are activated by stressors in vivo, whereas feeding bouts were associated with reduced activity of these neurons. Thus, PVH→LSv neurotransmission underlies dynamic feeding by orchestrating emotional states, providing a novel neural circuit substrate underlying comorbidity between eating abnormalities and psychiatric disorders.

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Citations

Jul 29, 2020·Nature Metabolism·Canjun ZhuQingchun Tong
May 10, 2020·Nature Communications·Ming-Dao MuYa Ke
Feb 10, 2021·Journal of Racial and Ethnic Health Disparities·Nelson HunAntonio López-Espinoza
Apr 8, 2021·Protein & Cell·Tiemin LiuDongsheng Cai

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Methods Mentioned

BETA
confocal microscopy

Software Mentioned

R
house
GraphPad Prism
Ethovision XT
ggplot2

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