Identification of a new antifungal oligoacetal derivative produced by Streptomyces toxytricini against Candida albicans

Natural Product Research
Ahmed Z Abdel AzeizSameh E Hasanein

Abstract

Thirty actinomycete isolates were isolated from soil and tested against Candida albicans in vitro. The active isolate was identified by 16s-rRNA gene sequencing method as Streptomyces toxytricini. The antifungal compound was extracted with ethyl acetate followed by diethyl ether. Both HPLC and GC-MS analysis confirmed presence of one pure compound in the diethyl ether extract. The compound is a yellow liquid has a maximum absorbance at 240 nm in methanol. The chemical structure was elucidated by 1D and 2D-NMR and IR analyses. The elucidated molecular formula was C36H54O14. The compound is a polyacetal tricyclononane derivative, composed of a tricyclononane ring attached from the carbon atom number four with an oligo-acetal chain (six acetal groups in chain) and from the carbon atom number seven with a methoxy carbonyl benzene-1,3-dicarboxylic acid. The purposed name is: 4- {[tricycle(3.2.1.1(1,3))non-8-yl] methoxy carbonyl benzene-1,3-dicarboxylic acid} (2,4,5,6,7,8,9 heptaoxa, 3-ethoxy, 5,6,7,9-tetramethyl unidecane).

References

Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Dec 19, 2000·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J Ferrer
Jul 27, 2001·Epidemiology and Infection·T L LamagniE M Johnson
Nov 25, 2004·Antimicrobial Agents and Chemotherapy·Donna M MacCallum, Frank C Odds
Sep 15, 2005·Journal of Medical Microbiology·C K MurrayD R Hospenthal
Jun 15, 2006·Journal of Medical Microbiology·D A EnochN M Brown
Apr 10, 2013·Asian Pacific Journal of Tropical Biomedicine·S ValliA Reena
Nov 19, 2013·Natural Product Research·Khaled A ShaabanJon S Thorson

❮ Previous
Next ❯

Citations

Apr 28, 2017·Frontiers in Microbiology·Lalitha CheepurupalliJayapradha Ramakrishnan

❮ Previous
Next ❯

Datasets Mentioned

BETA
HBUM174624

Methods Mentioned

BETA
NMR
PCR

Software Mentioned

Isis drawer
BLASTN
Wiley
BLAST

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.