Identification of a novel 120 bp allele at the TNFd microsatellite locus

Tissue Antigens
I J WastowskiE A Donadi

Abstract

Tumor necrosis factor-alpha (TNF-alpha) is a pro-inflammatory cytokine mainly secreted by macrophages and T-cells that play a key role in the pathogenesis of many infectious and inflammatory diseases. The TNF gene cluster is located within the class-III region of the highly polymorphic major histocompatibility complex on human chromosome 6p21. A cluster of six multiallelic microsatellites has been identified in the TNF region, named TNF a-e. TNFb, TNFc, TNFd, and TNFe are (GA)n repeats, whereas TNFa and TNFf are (GT)n and (CA)n repeats, respectively. The TNFd microsatellite locus maps 8-10 kb centromeric to the TNF-alpha gene, downstream to the TNF-beta gene.

References

Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C V JongeneelA Cambon-Thomsen
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Nov 13, 2001·Human Immunology·A H Hajeer, I V Hutchinson

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Citations

Jul 21, 2011·Indian Journal of Dermatology·Ahmad A SettinTahia A Hassan
Jan 5, 2022·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Isisdoris Rodrigues de SouzaDaniela Morais Leme

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