Identification of a novel cell cycle-related gene signature predicting survival in patients with gastric cancer

Journal of Cellular Physiology
Lan ZhaoMinjie Wei

Abstract

Gastric cancer (GC) is one of the most fatal cancers in the world. Thousands of biomarkers have been explored that might be related to survival and prognosis via database mining. However, the prediction effect of single gene biomarkers is not specific enough. Increasing evidence suggests that gene signatures are emerging as a possible better alternative. We aimed to develop a novel gene signature to improve the prognosis prediction of GC. Using the messenger RNA (mRNA)-mining approach, we performed mRNA expression profiling in a large GC cohort (n = 375) from The Cancer Genome Atlas (TCGA) database. Gene Set Enrichment Analysis (GSEA) was performed, and we recovered genes related to the G2/M checkpoint, which we identified with a Cox proportional regression model. We identified a set of five genes (MARCKS, CCNF, MAPK14, INCENP, and CHAF1A), which were significantly associated with overall survival (OS) in the test series. Based on this five-gene signature, the test series patients could be classified into high-risk or low-risk subgroups. Multivariate Cox regression analysis indicated that the prognostic power of this five-gene signature was independent of clinical features. In conclusion, we developed a five-gene signature rela...Continue Reading

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Citations

Oct 3, 2020·World Journal of Gastrointestinal Oncology·Kun-Zhe WuJin-Lan Jiang
Aug 28, 2020·Frontiers in Bioengineering and Biotechnology·Longxiang XieXiangqian Guo
Oct 21, 2020·Biomolecules & Therapeutics·Sun Young KimAree Moon
Apr 4, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Felipe Pantoja MesquitaRaquel Carvalho Montenegro
Apr 2, 2021·Journal of Clinical Laboratory Analysis·Qiaolian LiQiang Chen
Mar 30, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ang LiYanfang Jiang
Jun 13, 2021·Scientific Reports·Mengya HeRongguang Zhang
Sep 14, 2021·Frontiers in Genetics·Songling HanJingkui Tian
Oct 1, 2021·The Journal of International Medical Research·Shasha LiuXingbin Shen
Oct 19, 2021·Frontiers in Cell and Developmental Biology·Deli MaoChanghua Zhang

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