PMID: 11933063Apr 5, 2002Paper

Identification of a novel class in the alpha/beta hydrolase fold superfamily: the N-myc differentiation-related proteins

Proteins
Eudean ShawJonathan S Dordick

Abstract

The alpha/beta hydrolases constitute a large protein superfamily that mainly consists of enzymes that catalyze a diverse range of reactions. These proteins exhibit the alpha/beta hydrolase fold, the essential features of which have recently been delineated: the presence of at least five parallel beta-strands, a catalytic triad in a specific order (nucleophile-acid-histidine), and a nucleophilic elbow. Because of the difficulties experimentally in identifying protein structures, we have used a Bayesian computational algorithm (PROBE) to identify the members of this superfamily based on distant sequence relationships. We found that the presence of five sequence motifs, which contain residues important for substrate binding and stabilization of the fold, are required for membership in this superfamily. The superfamily consists of at least 909 members, including the N-myc downstream regulated proteins, which are believed to be involved in cell differentiation. Unlike most of the other superfamily members, the N-myc downstream regulated proteins have never been proposed to possess the alpha/beta hydrolase fold and do not appear to be hydrolases.

References

Apr 1, 1992·Protein Engineering·D L OllisJ Schrag
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·E KrejciJ Massoulié
Oct 25, 1990·Nucleic Acids Research·T D Schneider, R M Stephens
Apr 5, 1986·Journal of Molecular Biology·T D SchneiderA Ehrenfeucht
Jul 20, 1993·Journal of Molecular Biology·B Rost, C Sander
Jan 1, 1993·Annual Review of Biochemistry·A KolbS Adhya
Jun 1, 1996·Current Opinion in Structural Biology·J F GibratS H Bryant
May 1, 1997·Nucleic Acids Research·A F NeuwaldC E Lawrence
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Jun 27, 1998·Journal of Molecular Biology·B HofmannH J Hecht
Dec 23, 1999·Current Opinion in Structural Biology·M Nardini, B W Dijkstra
Jun 22, 2000·Journal of Molecular Biology·L A KelleyM J Sternberg

❮ Previous
Next ❯

Citations

Mar 8, 2006·Cell and Tissue Research·Xiao-Lan HuLi-Bo Yao
Mar 11, 2010·Extremophiles : Life Under Extreme Conditions·Rami Al KhudaryGarabed Antranikian
Jun 23, 2004·Neurobiology of Disease·Cathy MitchelmoreNiels A Jensen
Jul 12, 2012·Nature Reviews. Molecular Cell Biology·Colin Adrain, Matthew Freeman
Dec 19, 2003·Nucleic Acids Research·Thierry HotelierArnaud Chatonnet
Feb 20, 2007·Journal of Bacteriology·Aurelio Moraleda-Muñoz, Lawrence J Shimkets
Jul 23, 2009·Cancer Research·Grazia AmbrosiniGary K Schwartz
Oct 16, 2007·BMC Cancer·Anders LorentzenCathy Mitchelmore
May 11, 2004·Biological & Pharmaceutical Bulletin·Toshihiko SugikiIchiro Kudo
Sep 14, 2012·Molecular Biology Reports·Marcelo Dos SantosAdriana Madeira Álvares da Silva
Apr 3, 2012·Progress in Neurobiology·Cecilia BucciCinzia Progida
Jan 13, 2005·International Journal of Cancer. Journal International Du Cancer·Joseph T ChangAnn-Joy Cheng
Oct 18, 2003·American Journal of Human Genetics·Michael A SimpsonAndrew H Crosby
Apr 11, 2006·Developmental Biology·Zac PujicJarema Malicki
Apr 27, 2016·Apoptosis : an International Journal on Programmed Cell Death·Wei HuJianyuan Gao
Aug 12, 2009·Computers in Biology and Medicine·Christos LamprosDimitrios Tsalikakis
May 7, 2016·PloS One·Gangming Xu, Bin-Gui Wang
Nov 5, 2004·World Journal of Gastroenterology : WJG·Xiao-Lan HuLi-Bo Yao
Feb 27, 2004·The Journal of Biological Chemistry·James G BurchfieldCarsten Schmitz-Peiffer
Jul 30, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Veerle MelotteManon van Engeland
Aug 7, 2019·Therapeutic Advances in Gastroenterology·Chaoran YuMinhua Zheng
Nov 30, 2005·The Journal of Biological Chemistry·Baosheng ChenYoel Sadovsky
Apr 14, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Barbara M AgbemafleSusan J Henning

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.