Identification of a novel dehydroergosterol enhancing microglial anti-inflammatory activity in a dairy product fermented with Penicillium candidum

PloS One
Yasuhisa AnoHiroyuki Nakayama

Abstract

Despite the ever-increasing number of dementia patients worldwide, fundamental therapeutic approaches to treat this disease remain to be established. Preventive approaches such as diet, exercise and learning attract attention. Several epidemiological studies suggest that ingestion of fermented dairy products prevents cognitive decline in the elderly. These reports indicate that specific ingredients in the fermented dairy products elicit an anti-inflammatory or anti-oxidative activity that facilitates neuroprotection. The responsible components remain to be investigated. A number of studies have shown that inflammation caused by microglia is closely related to exaggeration of the pathology and cognitive decline seen in the elderly. Many researchers have proposed that controlling microglial activities could be effective in preventing and possibly curing dementia. In the present study, to elucidate specific compounds that regulate microglial activity from dairy products, repeated purification by HPLC, combined with evaluation using primary microglia, facilitated the identification of dehydroergosterol (DHE) as a novel component of the extract that enhances microglial anti-inflammatory activity. DHE contains three conjugated double...Continue Reading

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Citations

Nov 20, 2016·Virulence·George W KoutsourasLuis R Martinez
Jan 13, 2017·Preventive Nutrition and Food Science·Binna KimJieun E Kim
Jan 1, 2015·Lipid Insights·Katarzyna A SolankoDaniel Wüstner
Jan 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yasuhisa AnoKeiji Kondo
Jul 4, 2018·International Journal of Molecular Sciences·Yasuhisa Ano, Hiroyuki Nakayama
Jun 27, 2019·Journal of Agricultural and Food Chemistry·Yasuhisa AnoKeiji Kondo

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Methods Mentioned

BETA
transgenic
ELISA
cytokine
cytokine assay

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