Identification of a novel glial fibrillary acidic protein mRNA isotype related to memory retention in rats

Neuroreport
A M Huang, E H Lee

Abstract

Using the polymerase chain reaction (PCR) differential display directed to cloning transcripts related to retention performance for the inhibitory avoidance learning task, we have isolated two rat cDNA fragments homologous to the 3' untranslated region (3'UTR) of glial fibrillary acid protein (GFAP) cDNA. The GFAP upper cDNA represents a new GFAP mRNA isotype which has a 7 bp insertion in the 3'UTR. Further analyses indicated that retention performance in rats containing only the new GFAP mRNA isotype was significantly better than that of rats containing both the new GFAP mRNA isotype and the standard GFAP mRNA simultaneously. These results suggest that expression of the GFAP isotypes may be related to memory retention in rats.

References

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Citations

Mar 31, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Michael FountoulakisGert Lubec
May 8, 2002·Acta histochemica·Michail S DavidoffAdolf F Holstein
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Kuen J TsaiEminy H Y Lee
Jul 7, 2007·Human & Experimental Toxicology·F Monnet-TschudiP Honegger
Apr 11, 2015·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·E G SukhorukovaO S Alekseeva

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