Identification of a Novel HIV Type 1 CRF01_AE/CRF07_BC Recombinant Virus in Men Who Have Sex with Men in GuangXi, China

AIDS Research and Human Retroviruses
Weinan LiuYao Xiao

Abstract

This study reports a novel HIV-1 recombinant virus (GX2016EU10) isolated from a 24-year-old man, who was infected by homosexual sex in Guangxi, China. The near full-length genome analyses showed GX2016EU10 kept the CRF07_BC parental backbone with three CRF01_AE segments inserted into gag, pol, vpu, env, and nef genes, respectively. The recombinant breakpoints were completely different from the other CRF01_AE/CRF07_BC recombinant forms reported. GX2016EU10 was CCR5-tropic through GHOST cell identification. The emergence of GX2016EU10 indicates that the HIV-1 epidemic among men who have sex with men in Guangxi is increasing in complexity, which poses a serious challenge to prevention and control.

References

Apr 16, 2016·AIDS Research and Human Retroviruses·Xiaoshan LiPingmin Wei
Mar 14, 2017·AIDS Research and Human Retroviruses·Yan WangLiying Ma
May 31, 2017·AIDS Research and Human Retroviruses·Yuxueyun LiYiming Shao
Jun 7, 2017·AIDS Research and Human Retroviruses·Desheng KongLiying Ma

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Methods Mentioned

BETA
PCR

Software Mentioned

MEGA6
MEGA
jpHMM
MEGA5
RIP
ClustalW
Sequencher
SimPlot Bootscan
SimPlot
BioEdit

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