PMID: 8939153Nov 1, 1996Paper

Identification of a novel hydroxyproline-rich glycoprotein as the major allergen in Parthenium pollen

The Journal of Allergy and Clinical Immunology
N GuptaP V Rao

Abstract

The airborne pollen of the Compositae weed, Parthenium hysterophorus, is a major cause of allergic rhinitis in the Indian subcontinent and in certain parts of the southern United States and western Australia. Earlier studies have identified a 31 kd protein as the major allergen in Parthenium pollen. This study was undertaken to carry out the purification, immunochemical characterization, sequencing, and epitope analysis of this major allergen, designated as Par h I. The IgE-binding activity of the allergen was evaluated by immunoblot and inhibition ELISAs. Pronase digestion, periodate oxidation, and chemical deglycosylation were performed to determine the role of peptide and carbohydrate components of the allergen in IgE binding. The data provide evidence for the involvement of carbohydrate moieties on Par h 1 in its IgE-binding ability. The N-terminal 91 amino acid sequence of Par h 1 shows 81% identity with a protein from sunflower anther, and the hydroxyproline-rich region of Par h 1 is 30% to 40% identical to similar stretches in extensins, a class of hydroxyproline-rich cell wall glycoproteins from different plant species. IgE antibodies in the sera of individuals allergic to Parthenium cross-reacted with a 50 kd hydroxypr...Continue Reading

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Citations

Jan 1, 1997·Clinical Reviews in Allergy & Immunology·R C Aalberse, R van Ree
Jul 31, 2004·Current Allergy and Asthma Reports·Gabriele GadermaierFatima Ferreira
Jun 26, 2010·The Journal of Biological Chemistry·Renaud LéonardFriedrich Altmann
Mar 22, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P IacovacciG Di Felice
Mar 11, 2003·Clinical and Diagnostic Laboratory Immunology·Yee-Hsuan ChiouShiao-ping Huang
Dec 12, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Martin HimlyFátima Ferreira
Dec 14, 2004·The Journal of Biological Chemistry·Renaud LeonardFriedrich Altmann
Jul 22, 2017·Scientific Reports·Isabel PablosGabriele Gadermaier
Aug 31, 2019·BioMed Research International·Rafael de Oliveira ResendeErnesto Akio Taketomi
Feb 26, 2004·Allergy·F FerreiraA Mari
Apr 21, 2021·Environmental Monitoring and Assessment·Priyanka Srivastava, A S Raghubanshi
Jul 30, 2018·International Archives of Allergy and Immunology·Kashinath BhattacharyaSwati Gupta Bhattacharya

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