Identification of a novel microRNA profile in pediatric patients with cancer treated with anthracycline chemotherapy

American Journal of Physiology. Heart and Circulatory Physiology
Kelsie E OatmenFrancis G Spinale

Abstract

Anthracycline chemotherapy (AC) is associated with decline in left ventricular ejection fraction (LVEF), yet the mechanisms remain unclear. Although changes in microRNAs (miRs) have been identified in adult cardiovascular disease, miR profiles in pediatric patients with AC have not been well studied. The goal of this study was to examine miR profiles (unbiased array) in pediatric patients with AC compared with age-matched referent normal patients. We hypothesize that pediatric patients with AC will express a unique miR profile at the initiation and completion of therapy and will be related to LVEF. Serum was collected in pediatric patients (10-22 yr, n = 12) with newly diagnosed malignancy requiring AC within 24-48 h after the initiation of therapy (30-60 mg/m2) and ~1 yr after completing therapy. A custom microarray of 84 miRs associated with cardiovascular disease was used (quantitative RT-PCR) and indexed to referent normal profiles (13-17 yr, n = 17). LVEF was computed by cardiac MRI. LVEF fell from AC initiation at ~1 yr after AC completion (64.28 ± 1.78% vs. 57.53 ± 0.95%, respectively, P = 0.004). Of the 84 miRs profiled, significant shifts in 17 miRs occurred relative to referent normal ( P ≤ 0.05). Moreover, the functi...Continue Reading

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Citations

Nov 10, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Shambhabi ChatterjeeThomas Thum
Aug 9, 2020·Current Treatment Options in Oncology·Jenica N Upshaw
Apr 8, 2020·Journal of Veterinary Internal Medicine·Amelie BeaumierVicky K Yang
Jun 8, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Andreas M BeyerJavid Moslehi
Apr 19, 2021·Current Treatment Options in Oncology·Fei Fei GongNausheen Akhter

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Methods Mentioned

BETA
PCR
serum collection
coronary artery bypass

Software Mentioned

QMASS
GeneGlobe Data Analysis
GE CV
SPSS Statistics

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