PMID: 7541395Jul 4, 1995Paper

Identification of a novel peptide derived from the melanocyte-specific gp100 antigen as the dominant epitope recognized by an HLA-A2.1-restricted anti-melanoma CTL line

International Journal of Cancer. Journal International Du Cancer
A B BakkerC G Figdor

Abstract

Cytotoxic T lymphocytes (CTL) reactive with human melanoma tumor cells occasionally display cross-reactivity with normal melanocytes. Previously, we identified the melanocyte lineage-specific antigen gp 100 that is expressed by both melanoma cells and normal melanocytes, as a target antigen for tumor-infiltrating lymphocytes derived from a melanoma patient (TIL 1200). Here, we demonstrate that the oligoclonal HLA-A2.1-restricted TIL 1200 line is reactive with 2 distinct peptides derived from the gp 100 protein. Apart from the peptide corresponding to gp 100 amino acids 457-466, we identified the gp 100 peptide 154-162 as a second epitope recognized by TIL 1200. A 100-fold lower concentration of this novel gp 100 peptide was required for target-cell sensitization compared to peptide 457-466, indicating that the 154-162 peptide is the dominant gp 100 epitope for TIL 1200. Together with the recently described gp 100 280-288 epitope, 3 distinct CTL epitopes have now been identified in gp 100, all presented in the context of HLA-A2.1. Therefore, gp 100 is an attractive target antigen in the development of immuno-therapeutic protocols against melanoma.

References

May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·B Seed, A Aruffo
Jun 30, 1989·Cell·R H Schwartz
Jan 1, 1985·Immunogenetics·R D SalterP Cresswell
Apr 1, 1973·Virology·F L Graham, A J van der Eb
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·J ShilyanskyS A Rosenberg
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y KawakamiS A Rosenberg
Mar 1, 1994·The Journal of Experimental Medicine·A B BakkerC G Figdor
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y KawakamiS A Rosenberg

❮ Previous
Next ❯

Citations

Apr 28, 1999·Journal of Surgical Oncology·M R Hemmila, A E Chang
Jul 27, 1999·International Journal of Cancer. Journal International Du Cancer·J C SkipperC L Slingluff
Nov 1, 1996·Seminars in Surgical Oncology·C L Slingluff
Jul 31, 2001·International Journal of Cancer. Journal International Du Cancer·M GriffioenS Osanto
Jan 1, 1997·Immunologic Research·Y Kawakami, S A Rosenberg
Aug 17, 2004·Cancer Immunology, Immunotherapy : CII·Luisa NovellinoGiorgio Parmiani
Jun 8, 2001·Current Oncology Reports·K A Margolin
Apr 6, 1999·Pharmacology & Therapeutics·B R MinevM S Mitchell
Nov 22, 1997·Current Opinion in Immunology·B J Van den Eynde, P van der Bruggen
Apr 6, 2000·Current Opinion in Oncology·L H BrinckerhoffC L Slingluff
Oct 26, 2006·Journal of Immunotherapy·Michal LotemMaria R Parkhurst
Aug 1, 1997·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·M Browning, D Dunnion
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·N Le FurB Mintz
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·E JägerA Knuth
Sep 2, 1998·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·T S WangT M Johnson
Nov 8, 2008·Expert Opinion on Biological Therapy·Maria KatsaraVasso Apostolopoulos
Mar 21, 2002·Cancer Investigation·Jeffrey Weber
Apr 7, 2006·Molecular Immunology·Matthew A JosephWilson S Meng
May 20, 1998·Journal of the American Academy of Dermatology·T M JohnsonV K Sondak
Nov 21, 2007·Surgical Oncology Clinics of North America·Nicole M AgostinoPaul J Mosca
Aug 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I Jolanda M de VriesGosse J Adema
Nov 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rosalie M LuitenGijsbert C de Gast
Jan 10, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anthony E ZamoraPaul G Thomas
Mar 12, 1998·International Journal of Cancer. Journal International Du Cancer·I SaeterdalG Gaudernack
Jan 27, 1997·International Journal of Cancer. Journal International Du Cancer·A B BakkerC G Figdor
Nov 24, 1999·Immunological Reviews·R F Wang, S A Rosenberg
Oct 25, 2007·International Journal of Cancer. Journal International Du Cancer·Corlien A AarnoudseYvette van Kooyk
Oct 7, 2005·Autoimmunity·Selwyn ChowAnimesh A Sinha
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Galina V YamshchikovCraig L Slingluff
Jan 30, 2018·Current Medicinal Chemistry·Alexey V BaldinLyudmila V Savvateeva

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.