PMID: 8962150Dec 10, 1996Paper

Identification of a novel vertebrate circadian clock-regulated gene encoding the protein nocturnin

Proceedings of the National Academy of Sciences of the United States of America
Carla B Green, J C Besharse

Abstract

Photoreceptors of the Xenopus laevis retina are the site of a circadian clock. As part of a differential display screen for rhythmic gene products in this system, we have identified a photoreceptor-specific mRNA expressed in peak abundance at night. cDNA cloning revealed an open reading frame encoding a putative 388 amino acid protein that we have named "nocturnin" (for night-factor). This protein has strong sequence similarity to the C-terminal domain of the yeast transcription factor, CCR4, as well as a leucine zipper-like dimerization motif. Nocturnin mRNA levels exhibit a high amplitude circadian rhythm and nuclear run-on analysis indicates that it is controlled by the retinal circadian clock at the level of transcription. Our observations suggest that nocturnin may function through protein-protein interaction either as a component of the circadian clock or as a downstream effector of clock function.

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Citations

Jan 10, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E RosatoC P Kyriacou
May 14, 1998·Molecular Aspects of Medicine·A TaylorM Obin
Oct 24, 2000·Brain Research. Molecular Brain Research·M ZhuangJ C Besharse
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Oct 5, 2010·Cell Cycle·Beata Lecka-CzernikMasanobu Kawai

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