Identification of a Predominantly Interferon-λ-Induced Transcriptional Profile in Murine Intestinal Epithelial Cells

Frontiers in Immunology
Tharini A SelvakumarMathias W Hornef

Abstract

Type I (α and β) and type III (λ) interferons (IFNs) induce the expression of a large set of antiviral effector molecules via their respective surface membrane receptors. Whereas most cell types respond to type I IFN, type III IFN preferentially acts on epithelial cells and protects mucosal organs such as the lung and gastrointestinal tract. Despite the engagement of different receptor molecules, the type I and type III IFN-induced signaling cascade and upregulated gene profile is thought to be largely identical. Here, we comparatively analyzed the response of gut epithelial cells to IFN-β and IFN-λ2 and identified a set of genes predominantly induced by IFN-λ2. We confirm the influence of epithelial cell polarization for enhanced type III receptor expression and demonstrate the induction of predominantly IFN-λ2-induced genes in the gut epithelium in vivo. Our results suggest that IFN-λ2 targets the epithelium and induces genes to adjust the antiviral host response to the requirements at mucosal body sites.

References

Jun 22, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·D M Rennick, M M Fort
Apr 19, 2002·Molecular Biology and Evolution·Juan-Manuel IglesiasMaria-Pilar Fernandez
Dec 7, 2002·Nature Immunology·Paul SheppardKevin M Klucher
Dec 17, 2002·Nature Immunology·Sergei V KotenkoRaymond P Donnelly
Sep 12, 1957·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A ISAACS, J LINDENMANN
Jul 30, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Stephan BrandJulia Dambacher
Apr 12, 2006·The Journal of Experimental Medicine·Michael LotzMathias W Hornef
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sean E DoyleKevin M Klucher
Jan 6, 2007·The Journal of Biological Chemistry·Kazuhide OnoguchiTakashi Fujita
Jul 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hongchuan JinQian Tao
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pamela I OsterlundIlkka Julkunen
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nina AnkSøren R Paludan
Jul 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Scott J P ThomsonIrina A Udalova
Jan 28, 2010·Molecular Cancer Therapeutics·Kristan D GuenterbergWilliam E Carson
Feb 4, 2010·The Journal of Experimental Medicine·Manira RayamajhiLaurel L Lenz
Jun 25, 2010·Journal of Virology·Julia Elisabeth PulvererMario Köster
Dec 21, 2010·Annual Review of Immunology·Wenjun OuyangSarah G Hymowitz
Apr 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Johanna PottMathias W Hornef
Aug 6, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nikolaus JilgRaymond T Chung
Aug 10, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christopher R BolenSteven H Kleinstein
Oct 17, 2013·Mucosal Immunology·R E VandenbrouckeC Libert
Feb 6, 2014·PloS One·Pascale HermantThomas Michiels
Jun 24, 2014·Nature Immunology·Charlotte OdendallJonathan C Kagan
Aug 2, 2014·The Journal of Investigative Dermatology·Arianna CrespiGrazia Pietrini
Apr 23, 2015·Proceedings of the National Academy of Sciences of the United States of America·Fernando Souza-Fonseca-GuimaraesMark J Smyth
Nov 11, 2015·Drug Discovery Today·Ahmed LasfarKarine A Cohen-Solal
Sep 13, 2016·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Aoife KellyElizabeth J Ryan

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Citations

Jan 25, 2018·Viruses·Harshad IngleMegan T Baldridge
Jul 19, 2018·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ahmed LasfarKarine A Cohen-Solal
Aug 12, 2018·Molecular & Cellular Proteomics : MCP·Jiradej MakjaroenTrairak Pisitkun
Nov 18, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Min LiXian-Ming Chen
Jun 15, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Kalliopi PervolarakiMegan L Stanifer
Jul 22, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohamed BenhammadiClaude Perreault
Jun 16, 2019·Nature Reviews. Immunology·Liang YePeter Staeheli
Apr 19, 2020·Science Immunology·Margaux HubertJenny Valladeau-Guilemond
May 24, 2019·Viruses·Alexandra I Wells, Carolyn B Coyne
Nov 1, 2018·Molecular & Cellular Proteomics : MCP·Jiradej MakjaroenTrairak Pisitkun
Sep 17, 2018·Trends in Immunology·Alexandra I Wells, Carolyn B Coyne
Apr 29, 2021·Nature Reviews. Rheumatology·Rishi R GoelMariana J Kaplan
Aug 27, 2021·Blood·Andrea S HendenGeoffrey R Hill
Oct 27, 2021·The Journal of General Virology·Aminu S Jahun, Ian G Goodfellow

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Datasets Mentioned

BETA
GPL11202
GSE91382

Methods Mentioned

BETA
transgenic
IECs
PCR
feature extraction
GTPase

Software Mentioned

GraphPad Prism
Feature Extraction
PANTHER
Qlucore Omics explorer

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