Identification of a PTH regulated gene selectively induced in vivo during PTH-mediated bone formation

Journal of Cellular Biochemistry
John A RobinsonFred Bex

Abstract

The biological activities of parathyroid hormone (PTH) on bone are quite complex as demonstrated by its catabolic and anabolic activities on the skeleton. Although there have been many reports describing genes that are regulated by PTH in osteoblast cells, the goal of this study was to utilize a well-established in vivo PTH anabolic treatment regimen to identify genes that mediate bone anabolic effects of PTH. We identified a gene we named PTH anabolic induced gene in bone (PAIGB) that has been reported as brain and acute leukemia cytoplasmic (BAALC). Therefore, using the latter nomenclature, we have discovered that BAALC is a PTH-regulated gene whose mRNA expression was selectively induced in rat tibiae nearly 100-fold (maximal) by a PTH 1-34 anabolic treatment regimen in a time-dependent manner. Although BAALC is broadly expressed, PTH did not regulate BAALC expression in other PTH receptor expressing tissues and we find that the regulation of BAALC protein by PTH in vivo is confined to mature osteoblasts. Further in vitro studies using rat UMR-106 osteoblastic cells show that PTH 1-34 rapidly induces BAALC mRNA expression maximally by 4 h while the protein was induced by 8 h. In addition to being regulated by PTH 1-34, BAALC...Continue Reading

References

Sep 28, 1990·Biochemical and Biophysical Research Communications·B R ChakravarthyJ F Whitfield
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T K GrayL M Nabell
Jun 26, 1986·The New England Journal of Medicine·B L Riggs, L J Melton
Jan 1, 1984·Archives of Oral Biology·D FarrR Dziak
Dec 25, 1994·Nucleic Acids Research·P LiangA B Pardee
Jul 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·V L DavisK S Korach
Jul 1, 1994·Journal of Cellular Biochemistry·L F Bonewald, S L Dallas
Aug 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R H RixonW Sung
Dec 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B Fermor, T M Skerry
Oct 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y IsogaiT Suda
Mar 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R Armamento-VillarealR Civitelli
Feb 5, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D Goltzman
Aug 17, 1999·The Journal of Clinical Investigation·R L JilkaS C Manolagas
Sep 1, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P C SchillerG A Howard
Jan 26, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L C HofbauerB L Riggs
May 29, 2001·Current Pharmaceutical Design·S R Hoare, T B Usdin
Nov 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·S M TannerA de La Chapelle
Jan 30, 2002·Gene·John T SwarthoutNicola C Partridge
Jul 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Armen H Tashjian, Bruce A Chabner
Feb 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Laura P Zanello, Anthony W Norman
Feb 28, 2004·Molecular Endocrinology·Johanna LammiPiia Aarnisalo
Mar 24, 2004·Trends in Endocrinology and Metabolism : TEM·Ling QinNicola C Partridge

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Citations

Jun 8, 2013·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·M WolfS Lossdörfer
Apr 10, 2012·Biochimica Et Biophysica Acta·Diana A StavrevaGordon L Hager
Jan 31, 2009·Journal of Cellular Biochemistry·Richard J MurrillsPeter V N Bodine
Apr 3, 2007·Bone Marrow Transplantation·K Ballen

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