PMID: 8604548Nov 1, 1995Paper

Identification of a region of the alcelaphine herpesvirus-1 genome associated with virulence for rabbits

Veterinary Microbiology
J A HandleyH W Reid

Abstract

The gammaherpesvirus Alcelaphine Herpesvirus 1 (AHV-1) causes the fatal lymphoproliferative disease known as malignant catarrhal fever (MCF), in susceptible hosts. The virulent C500 isolate of AHV-1 became attenuated for the laboratory model, the rabbit, as a result of serial passage in cells of bovine origin. This work describes the identification of a region of the central unique sequence of the C500 genome, located close to the terminal repeat units of the molecule, which is altered on attenuation. The virulent C500 genome contains two copies of a sequence of approximately 2 kbp, contained within a 7 kbp region of the unique DNA located adjacent to the terminal repeats at the left end of the molecule. In the genome of the attenuated virus, there are also two copies of the 2 kbp sequence but they are located at the ends of the attenuated genome unique region, adjacent to the terminally repeated sequences. One open reading frame (ORF), designated putative polypeptide 5, was altered on attenuation such that the 3' sequence was lost. The location of this ORF, coupled with the loss of its 3' sequence, suggests that this ORF may encode a gene involved in the virulent mechanisms of this virus, in a manner similar to that of the tra...Continue Reading

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Citations

Nov 21, 2007·Veterinary Research Communications·F M Frame, R G Dalziel
Mar 21, 2008·Journal of Virology·Inga DryGeorge C Russell
Jun 29, 2001·Journal of Comparative Pathology·L J CoulterH W Reid
Dec 10, 2015·Archives of Virology·Inga DryGeorge C Russell
Mar 12, 2008·Journal of Comparative Pathology·I E AndersonD M Haig
Nov 11, 2014·Annual Review of Animal Biosciences·Hong LiDonald P Knowles

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