Identification of a RING protein that can interact in vivo with the BRCA1 gene product

Nature Genetics
L C WuRichard Baer

Abstract

The hereditary breast and ovarian cancer gene, BRCA1, encodes a large polypeptide that contains the cysteine-rich RING motif, a zinc-binding domain found in a variety of regulatory proteins. Here we describe a novel protein that interacts in vivo with the N-terminal region of BRCA1. This BRCA1-associated RING domain (BARD1) protein contains an N-terminal RING motif, three tandem ankyrin repeats, and a C-terminal sequence with significant homology to the phylogenetically conserved BRCT domains that lie near the C terminus of BRCA1. The BARD1/BRCA1 interaction is disrupted by BRCA1 missense mutations that segregate with breast cancer susceptibility, indicating that BARD1 may be involved in mediating tumour suppression by BRCA1.

References

Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C T ChienS Fields
Feb 1, 1991·Molecular and Cellular Biology·C V DangE R Fearon
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Oct 7, 1994·Science·P A FutrealY Miki
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·H L HsuR Baer
Dec 1, 1995·Human Molecular Genetics·S K SharanA Bradley
Jul 1, 1996·Nature Genetics·E V KooninP Bork
Jun 1, 1996·Trends in Biochemical Sciences·A J SaurinP S Freemont

❮ Previous
Next ❯

Citations

Dec 29, 1999·Genes, Chromosomes & Cancer·J HuE J Perlman
Aug 30, 2000·International Journal of Cancer. Journal International Du Cancer·K YoshikawaR Takahashi
Aug 5, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C X Deng, S G Brodie
Nov 11, 2011·Archives of Toxicology·Christos T ChasapisMaria E Stefanidou
Jan 1, 2013·Pediatric Surgery International·Raquel Domingo-FernandezIsabella Bray
Mar 3, 2007·Breast Cancer Research and Treatment·Anna JakubowskaJan Lubiński
Nov 1, 2007·Breast Cancer Research and Treatment·Kylie L GorringeIan G Campbell
May 16, 2008·Breast Cancer Research and Treatment·Sharon E JohnattyUNKNOWN Kathleen Cuningham Consortium for Research in Familial Breast Cancer
May 27, 2008·Breast Cancer Research and Treatment·Thomas V O HansenFinn C Nielsen
Jun 12, 2008·Breast Cancer Research and Treatment·Thomas v O HansenFinn C Nielsen
Sep 30, 2010·Breast Cancer Research and Treatment·Apichart AtipairinAdisorn Ratanaphan
Jul 3, 2010·Science China. Life Sciences·Li Cui, Wei Li
Apr 6, 2012·Archives of Pharmacal Research·Jung Hoon Lee, Min Jae Lee
Sep 3, 2003·Biochemical and Biophysical Research Communications·S TascouP Burfeind
Nov 25, 2004·Progress in Biophysics and Molecular Biology·Paul A NguewaJosé M Pérez
Jan 18, 2003·Experimental Cell Research·Megan Fabbro, Beric R Henderson
Aug 29, 2003·The Journal of Surgical Research·T J WestmorelandC B Bennett
Aug 26, 2000·Cancer Genetics and Cytogenetics·Y Patael-KarasikE Friedman
Feb 28, 2003·Cancer Genetics and Cytogenetics·Simona AgataMarco Montagna
Feb 25, 2000·Cancer Genetics and Cytogenetics·H TworekR A DiCioccio
Feb 1, 2000·Trends in Genetics : TIG·P L WelcshM C King
Mar 20, 2002·Biochimie·Ralph Scully, Nadine Puget
Dec 2, 1999·Molecular and Cellular Endocrinology·M Schuyer, E M Berns
Oct 11, 2003·Cancer Letters·Makoto IshitobiShinzaburo Noguchi
Nov 10, 2000·International Journal of Radiation Oncology, Biology, Physics·T LeongM McKay
Aug 18, 2000·Mutation Research·T HuytonP S Freemont
Jan 16, 2002·Current Opinion in Genetics & Development·Richard Baer, Thomas Ludwig
Oct 26, 2000·Trends in Biochemical Sciences·A N Monteiro
Apr 12, 2002·The International Journal of Biochemistry & Cell Biology·Irmgard Irminger-Finger, Wai Choi Leung
Jul 29, 1998·Molecular Medicine Today·J Feunteun
Dec 6, 2001·Trends in Molecular Medicine·M Futaki, J M Liu
Jun 16, 1999·Breast Cancer Research and Treatment·X Yang, M E Lippman
Jun 26, 2004·Breast Cancer Research and Treatment·Monica M ReinholzThomas C Spelsberg
Dec 2, 2000·Nature·R Scully, D M Livingston
May 21, 2011·Cell Death and Differentiation·J H JungJ H Lee
Oct 2, 2004·Nature Cell Biology·Alan Ashworth
May 5, 2009·Nature Genetics·Mario CapassoJohn M Maris
Sep 3, 2004·Nature Reviews. Cancer·Steven A Narod, William D Foulkes
Apr 25, 2006·Nature Reviews. Cancer·Irmgard Irminger-Finger, Charles Edward Jefford

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.