PMID: 8944637Nov 1, 1996Paper

Identification of a second region of the beta-subunit involved in regulation of calcium channel inactivation

The American Journal of Physiology
N QinEnrico Stefani

Abstract

Previous studies have shown that NH2 termini of the type 1 and 2 beta-subunits modulate the rate at which the neuronal alpha 1E calcium channel inactivates in response to voltage and that they do so independently of their common effect to stimulate activation by voltage (R. Olcese, N. Qin, T. Schneider, A. Neely, X. Wei, E. Stefani, and L. Birnbaumer, Neuron 13: 1433-1438, 1994). By constructing NH2-terminal deletions of several splice variants of beta-subunits, we have now found differences in the way they affect the rate of alpha 1E inactivation that lead us to identify a second domain that also regulates the rate of voltage-induced inactivation of the Ca2+ channel. This second domain, named segment 3, lies between two regions of high-sequence identity between all known beta-subunits and exists in two lengths (long and short), each encoded in a separate exon. Beta-Subunits with the longer 45- to 53-amino acid version cause the channel to inactivate more slowly than subunits with the shorter 7-amino acid version. As is the case for the NH2 terminus, the segment 3 does not affect the regulation of channel activation by the beta-subunit. In addition, the effect of the NH2-terminal segment prevails over that of the internal segme...Continue Reading

References

Jul 28, 1995·The Journal of Biological Chemistry·D R WitcherK P Campbell
Aug 1, 1994·Neuron·M De WaardK P Campbell

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Citations

Apr 28, 1997·FEBS Letters·A Marquart, V Flockerzi
Jun 5, 1998·The American Journal of Physiology·N QinL Birnbaumer
Jan 15, 2004·The Journal of Biological Chemistry·Julio AlvarezGuy Vassort
May 31, 2007·The Journal of General Physiology·Olga BabichRoman Shirokov
Apr 19, 2008·BMC Molecular Biology·Alicia M EbertDeborah M Garrity
Aug 30, 2008·The Journal of General Physiology·Giovanni Gonzalez-GutierrezAlan Neely
Jan 15, 2017·The Journal of General Physiology·Cheon-Gyu ParkByung-Chang Suh
Feb 20, 1999·The Journal of Biological Chemistry·T CensP Charnet
Dec 16, 2006·Pflügers Archiv : European journal of physiology·Norbert WeissMichel De Waard
Jun 5, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Vadim GudzenkoRiccardo Olcese
Oct 21, 2010·Physiological Reviews·Zafir Buraei, Jian Yang
Aug 12, 2009·Aging Cell·Jackson R TaylorOsvaldo Delbono
Nov 7, 2003·The Journal of Biological Chemistry·Stephanie C StotzGerald W Zamponi
Apr 29, 1998·Trends in Neurosciences·D Walker, M De Waard

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